The effect of artichoke (Cynara scolymus L.) extract on ROS generation in HUVEC cells

被引：14
|
作者：
Juzyszyn, Z. [1 ]
Czerny, B. [2 ]
Pawlik, A. [3 ]
Drozdzik, M. [1 ]
机构：
[1] Pomeranian Med Univ, Dept Expt & Clin Pharmacol, PL-70111 Szczecin, Poland
[2] Pomeranian Med Univ, Dept Drug Toxicol & Pharmacoecon, PL-70111 Szczecin, Poland
[3] Pomeranian Med Univ, Dept Pharmacokinet & Therapeut Drug Monitoring, PL-70111 Szczecin, Poland
来源：
PHYTOTHERAPY RESEARCH | 2008年 / 22卷 / 09期
关键词：
artichoke extract; antioxidants; ROS; HUVECs;
D O I：
10.1002/ptr.2385
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The effect of an artichoke extract on induced reactive oxygen species (ROS) generation in cultured human umbilical endothelial cells (HUVECs) and its reductive properties were evaluated. Preincubation of HUVEC cells with the artichoke extract at concentrations of 25-100 mu g/mL for 24 h abolished ROS generation induced by LPS and oxyLDL as evaluated by the fluorescence intensity of 2',7'-dichlorofluorescein (DCF). Potent, concentration-dependent reductive properties of the artichoke extract were demonstrated by the reduction kinetics of cytochrome c in reference to ascorbate were also revealed. The results of the present study the warrant application of artichoke extracts as endothelium protecting agents. Copyright (c) 2008 John Wiley & Sons, Ltd.
引用
收藏
页码：1159 / 1161
页数：3
相关论文
共 50 条
  • [1] In Vivo Genotoxicity Evaluation of an Artichoke (Cynara scolymus L.) Aqueous Extract
    Zan, Meriele A.
    Ferraz, Alexandre B. F.
    Richter, Marc F.
    Picada, Jaqueline N.
    de Andrade, Heloisa H. R.
    Lehmann, Mauricio
    Dihl, Rafael R.
    Nunes, Emilene
    Semedo, Juliane
    Da Silva, Juliana
    JOURNAL OF FOOD SCIENCE, 2013, 78 (02) : T367 - T371
  • [2] Antioxidant and Antimicrobial Potential of Artichoke (Cynara scolymus L.) Extract in Beef Patties
    Ergezer, Haluk
    Kaya, Halil Ibrahim
    Simsek, Omer
    CZECH JOURNAL OF FOOD SCIENCES, 2018, 36 (02) : 154 - 162
  • [3] Herbicide Tests in Artichoke (Cynara scolymus L.) in Thuringia
    Schmatz, Ruediger
    Plescher, Andreas
    Schaekel, Christine
    Dick, Christian
    GESUNDE PFLANZEN, 2012, 64 (01): : 21 - 27
  • [4] Study of the Structure of Artichoke (Cynara scolymus L.) Flowers
    Basay, S.
    JOURNAL OF AGRICULTURAL SCIENCE AND TECHNOLOGY, 2022, 24 (04): : 913 - 924
  • [5] The Effect of Artichoke (Cynara scolymus L.) Extract on Respiratory Chain System Activity in Rat Liver Mitochondria
    Juzyszyn, Z.
    Czerny, B.
    Mysliwiec, Z.
    Pawlik, A.
    Drozdzik, M.
    PHYTOTHERAPY RESEARCH, 2010, 24 : S123 - S128
  • [6] The influence of supplementation with artichoke (Cynara scolymus L.) extract on selected redox parameters in rowers
    Skarpanska-Stejnborn, Anna
    Pilaczynska-Szczesniak, Lucia
    Basta, Piotr
    Deskur-Smielecka, Ewa
    Horoszkiewicz-Hassan, Magorzata
    INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, 2008, 18 (03) : 313 - 327
  • [7] Isolation, characterization and determination of minor artichoke (Cynara scolymus L.) leaf extract compounds
    Fritsche, J
    Beindorff, CM
    Dachtler, M
    Zhang, H
    Lammers, JG
    EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 2002, 215 (02) : 149 - 157
  • [8] Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities
    Zhu, XF
    Zhang, HX
    Lo, R
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2004, 52 (24) : 7272 - 7278
  • [9] Isolation, characterization and determination of minor artichoke (Cynara scolymus L.) leaf extract compounds
    Jan Fritsche
    Christaan M. Beindorff
    Markus Dachtler
    Hui Zhang
    Jan G. Lammers
    European Food Research and Technology, 2002, 215 : 149 - 157
  • [10] Effect of soil salinity on artichoke (Cynara cardunculus [L.] subsp scolymus Hayek)
    Cantore, V
    Boaril, F
    Bianchimano, V
    Bianco, VV
    PROCEEDINGS OF THE VTH INTERNATIONAL CONGRESS ON ARTICHOKE, 2004, (660): : 311 - 316
12345