Asymmetric total synthesis of 5′-epi-paecilomycin-F

被引：25
作者：
Jana, Nandan [1 ]
Nanda, Samik [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India
来源：
TETRAHEDRON-ASYMMETRY | 2012年 / 23卷 / 10期
关键词：
RESORCYLIC ACID LACTONES; DYNAMIC KINETIC RESOLUTION; KINASE INHIBITOR; AIGIALOMYCIN-D; ESTROGENIC ACTIVITY; RUTHENIUM; RADICICOL; LL-Z1640-2; ALCOHOLS; MACROLIDES;
D O I：
10.1016/j.tetasy.2012.05.017
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The asymmetric total synthesis of one of the stereoisomers of the naturally occurring 14-membered ring macrolide paecilomycin-F (5'-epi) has been reported in this article. The main highlight of the synthetic strategy involves the successful application of a ring closing metathesis (RCM) reaction at a late stage. Asymmetric Keck allylation, Sharpless asymmetric dihydroxylation, and Mitsunobu esterification have also been used successfully for the total synthesis of 5'-epi-paecilomycin-F. (C) 2012 Elsevier Ltd. All rights reserved.
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页码：802 / 808
页数：7
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