Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment

被引：31

作者：

Cai, Qingqing ^{[1
]}

Fang, Yu ^{[1
]}

Young, Ken H. ^{[2
]}

机构：

[1] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Dept Med Oncol,Canc Ctr, Guangzhou 510060, Guangdong, Peoples R China

[2] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, 1515 Holcombe Blvd, Houston, TX 77030 USA

来源：

TRANSLATIONAL ONCOLOGY | 2019年 / 12卷 / 03期

基金：

中国国家自然科学基金;

关键词：

PRIMARY CNS LYMPHOMA; HIGH-DOSE CHEMOTHERAPY; WHOLE-BRAIN RADIOTHERAPY; STEM-CELL TRANSPLANTATION; INTERNATIONAL EXTRANODAL LYMPHOMA; RECURRENT PRIMARY CNS; UNDER-THE-CURVE; SALVAGE THERAPY; INTENSIVE CHEMOTHERAPY; 1ST-LINE TREATMENT;

D O I：

10.1016/j.tranon.2018.11.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Primary central nervous system lymphoma (PCNSL) is a group of extranodal non-Hodgkin lymphoma that exhibits specific biological characteristics and clinical behavior, with an aggressive disease course and unsatisfactory patient outcomes. It is of great importance to identify aberrant genetic loci and important molecular pathways that might suggest potential targets for new therapeutics and provide prognostic information. In this review, we listed various genetic and epigenetic alterations that are involved in PCNSL pathogenesis. In the aspect of treatment, we summarized the related literatures and evaluated the efficacy of surgery, induction chemotherapy, radiotherapy, intrathecal chemotherapy, and autologous stem cell transplantation in PCNSL. We also proposed the possible new agents for recurrent and relapse PCNSL based on the result of recent clinical researches.

引用

页码：523 / 538

页数：16

共 139 条

[91]

Nayak Lakshmi, 2015, Continuum (Minneap Minn), V21, P355, DOI 10.1212/01.CON.0000464175.96311.0a

[92] Late relapse in primary central nervous system lymphoma: clonal persistence [J].

Nayak, Lakshmi ;

Hedvat, Cyrus ;

Rosenblum, Marc K. ;

Abrey, Lauren E. ;

DeAngelis, Lisa M. .

NEURO-ONCOLOGY, 2011, 13 (05) :525-529

[93] NON-HODGKINS-LYMPHOMA OF THE BRAIN - CAN HIGH-DOSE, LARGE VOLUME RADIATION-THERAPY IMPROVE SURVIVAL - REPORT ON A PROSPECTIVE TRIAL BY THE RADIATION-THERAPY-ONCOLOGY-GROUP (RTOG) - RTOG-8315 [J].

NELSON, DF ;

MARTZ, KL ;

BONNER, H ;

NELSON, JS ;

NEWALL, J ;

KERMAN, HD ;

THOMSON, JW ;

MURRAY, KJ .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1992, 23 (01) :9-17

[94] PRIMARY CNS LYMPHOMA TREATED WITH OSMOTIC BLOOD-BRAIN-BARRIER DISRUPTION - PROLONGED SURVIVAL AND PRESERVATION OF COGNITIVE FUNCTION [J].

NEUWELT, EA ;

GOLDMAN, DL ;

DAHLBORG, SA ;

CROSSEN, J ;

RAMSEY, F ;

ROMANGOLDSTEIN, S ;

BRAZIEL, R ;

DANA, B .

JOURNAL OF CLINICAL ONCOLOGY, 1991, 9 (09) :1580-1590

[95] Oncogenically active MYD88 mutations in human lymphoma [J].

Ngo, Vu N. ;

Young, Ryan M. ;

Schmitz, Roland ;

Jhavar, Sameer ;

Xiao, Wenming ;

Lim, Kian-Huat ;

Kohlhammer, Holger ;

Xu, Weihong ;

Yang, Yandan ;

Zhao, Hong ;

Shaffer, Arthur L. ;

Romesser, Paul ;

Wright, George ;

Powell, John ;

Rosenwald, Andreas ;

Muller-Hermelink, Hans Konrad ;

Ott, German ;

Gascoyne, Randy D. ;

Connors, Joseph M. ;

Rimsza, Lisa M. ;

Campo, Elias ;

Jaffe, Elaine S. ;

Delabie, Jan ;

Smeland, Erlend B. ;

Fisher, Richard I. ;

Braziel, Rita M. ;

Tubbs, Raymond R. ;

Cook, J. R. ;

Weisenburger, Denny D. ;

Chan, Wing C. ;

Staudt, Louis M. .

NATURE, 2011, 470 (7332) :115-U133

[96] The changing incidence of primary central nervous system lymphoma is driven primarily by the changing incidence in young and middle-aged men and differs from time trends in systemic diffuse large B-cell non-Hodgkin's lymphoma [J].

O'Neill, Brian Patrick ;

Decker, Paul A. ;

Tieu, Christina ;

Cerhan, James R. .

AMERICAN JOURNAL OF HEMATOLOGY, 2013, 88 (12) :997-1000

[97] Targeting of somatic hypermutation [J].

Odegard, Valerie H. ;

Schatz, David G. .

NATURE REVIEWS IMMUNOLOGY, 2006, 6 (08) :573-583

[98] Primary CNS lymphoma in patients younger than 60: can whole-brain radiotherapy be deferred? [J].

Omuro, A. ;

Taillandier, Luc ;

Chinot, Olivier ;

del Rio, Monica Sierra ;

Carnin, Charlotte ;

Barrie, Marylin ;

Soussain, Carole ;

Tanguy, Marie-Laure ;

Choquet, Sylvain ;

Leblond, Veronique ;

Hoang-Xuan, Khe .

JOURNAL OF NEURO-ONCOLOGY, 2011, 104 (01) :323-330

[99] Methotrexate and temozolomide versus methotrexate, procarbazine, vincristine, and cytarabine for primary CNS lymphoma in an elderly population: an intergroup ANOCEF-GOELAMS randomised phase 2 trial [J].

Omuro, Antonio ;

Chinot, Olivier ;

Taillandier, Luc ;

Ghesquieres, Herve ;

Soussain, Carole ;

Delwail, Vincent ;

Lamy, Thierry ;

Gressin, Remy ;

Choquet, Sylvain ;

Soubeyran, Pierre ;

Huchet, Aymeri ;

Benouaich-Amiel, Alexandra ;

Lebouvier-Sadot, Sophie ;

Gyan, Emmanuel ;

Touitou, Valerie ;

Barrie, Maryline ;

del Rio, Monica Sierra ;

Gonzalez-Aguilar, Alberto ;

Houillier, Caroline ;

Delgadillo, Daniel ;

Lacomblez, Lucette ;

Tanguy, Marie Laure ;

Hoang-Xuan, Khe .

LANCET HAEMATOLOGY, 2015, 2 (06) :E251-E259

[100] R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma [J].

Omuro, Antonio ;

Correa, Denise D. ;

DeAngelis, Lisa M. ;

Moskowitz, Craig H. ;

Matasar, Matthew J. ;

Kaley, Thomas J. ;

Gavrilovic, Igor T. ;

Nolan, Craig ;

Pentsova, Elena ;

Grommes, Christian C. ;

Panageas, Katherine S. ;

Baser, Raymond E. ;

Faivre, Geraldine ;

Abrey, Lauren E. ;

Sauter, Craig S. .

BLOOD, 2015, 125 (09) :1403-1410

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