Cytokine Network: New Targeted Therapy for Pancreatic Cancer

被引：34

作者：

Matsuo, Yoichi ^{[1
]}

Takeyama, Hiromitsu

Guha, Sushovan ^{[2
]}

机构：

[1] Nagoya City Univ, Dept Surg Gastroenterol, Grad Sch Med Sci, Mizuho Ku, Nagoya, Aichi 4678601, Japan

[2] Univ Texas MD Anderson Canc Ctr, Dept Gastroenterol Hepatol & Nutr, Houston, TX 77030 USA

来源：

CURRENT PHARMACEUTICAL DESIGN | 2012年 / 18卷 / 17期

关键词：

Pancreatic cancer; cytokine; angiogenesis; targeted therapy; HEPATOCYTE GROWTH-FACTOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST; TUMOR-GROWTH; IN-VITRO; PROMOTES ANGIOGENESIS; CHEMOKINE RECEPTORS; BIOLOGICAL AXIS; MELANOMA-CELLS; HGF SECRETION; EXPRESSION;

D O I：

10.2174/13816128112092416

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Increasing evidence has shown that cytokines have a role in tumor biology. The role of chemokines in tumor biology is important because these peptides may influence tumor growth, invasion, angiogenesis, and metastasis. In this review, we demonstrated the role of cytokines (Interleukin-1 alpha, hepatocyte growth factor, Interleukin-8, stromal cell-derived factor-1 and CXC-chemokines/CXCR2 biological axis) in pancreatic cancer angiogenesis, especially from the standpoint of the interaction between tumor and its microenvironments. The cytokines are intimately related with cancer angiogenesis. Blocking these cytokines could attenuate pancreatic cancer associated angiogenesis and further considered as a novel anti-angiogenic target in pancreatic cancer.

引用

页码：2416 / 2419

页数：4

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