Biofunctionality of self-assembled nanolayers composed of cellulosic polymers

被引：22
作者：
Yokota, Shingo [1 ]
Kitaoka, Takuya [1 ]
Wariishi, Hiroyuki [1 ]
机构：
[1] Kyushu Univ, Dept Forest & Forest Prod Sci, Grad Sch Bioresource & Bioenvironm Sci, Higashi Ku, Fukuoka 8128581, Japan
来源：
CARBOHYDRATE POLYMERS | 2008年 / 74卷 / 03期
基金：
日本学术振兴会;
关键词：
cellulosic polymer; biointerface; surface morphology; cell attachment; self-assembly;
D O I：
10.1016/j.carbpol.2008.04.027
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Biofunctional cellulosic interfaces were successfully designed via the self-assembly of cellulose and its derivatives whose reducing ends were selectively modified with thiosemicarbazide. The biological functions of cellulosic self-assembled monolayers (SAMs) formed on a gold surface were investigated using rat liver cells. The cells proliferated well on the cellulose SAM (cellulose I) and methylcellulose SAM, while almost no cells adhered to the regenerated cellulose film (cellulose II) and hydroxyethylcellulose SAM. In the initial cell adhesion, rat liver cells were moderately attached on the cellulose SAM even in serum-free culture, possibly suggesting specific interactions between cells and cellulose SAM with unique surface morphology. The architectural design of cellulosic nanolayers via peculiar vectorial chain immobilization is expected to provide new information for the functional development of structural polysaccharide-based biointerfaces. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：666 / 672
页数：7
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