Gonorrhea and Chlamydia Case Detection Increased When Testing Increased in a Multisite US HIV Cohort, 2004-2014

被引:16
作者
Raifman, Julia R. [1 ]
Gebo, Kelly A. [2 ]
Mathews, William Christopher [3 ]
Korthuis, Philip Todd [4 ]
Ghanem, Khalil G. [2 ]
Aberg, Judith A. [5 ]
Moore, Richard D. [2 ]
Nijhawan, Ank E. [6 ]
Monroe, Anne K. [2 ]
Berry, Stephen A. [2 ]
机构
[1] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD USA
[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA
[3] Univ Calif San Diego, Dept Med, Sch Med, San Diego, CA 92103 USA
[4] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA
[5] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA
[6] Univ Texas Southwestern Med Ctr Dallas, Dept Med, Dallas, TX 75390 USA
关键词
guidelines; gonorrhea; chlamydia; MSM; women; prevention among positives; SEXUALLY-TRANSMITTED INFECTIONS; NEISSERIA-GONORRHOEAE; CLINICAL COHORT; MEN; SEX; CARE; TRACHOMATIS; PERFORMANCE; PREVALENCE; PREVENTION;
D O I
10.1097/QAI.0000000000001514
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objectives: Annual screening for gonorrhea [Neisseria gonorrhoeae (NG)] and chlamydia [Chlamydia trachomatis (CT)] is recommended for all sexually active persons living with HIV but is poorly implemented. Studies demonstrating no increases in NG and/or CT (NG/CT) case detection in clinics that successfully expanded NG/CT screening raise questions about this broad screening approach. We evaluated NG/CT case detection in the HIV Research Network during 2004-2014, a period of expanding testing. Methods: We analyzed linear time trends in annual testing (patients tested divided by all patients in care), test positivity (patients positive divided by all tested), and case detection (the number of patients with a positive result divided by all patients in care) using multivariate repeated measures logistic regression. We determined trends overall and stratified by men who have sex with men (MSM), men who have sex exclusively with women, and women. Results: Among 15,614 patients (50% MSM, 26% men who have sex exclusively with women, and 24% women), annual NG/CT testing increased from 22% in 2004 to 60% in 2014 [adjusted odds ratio (AOR) per year 1.22 (1.21-1.22)]. Despite the increase in testing, test positivity also increased [AOR per year 1.10 (1.07-1.12)], and overall case detection increased from 0.8% in 2004 to 3.9% in 2014 [AOR per year 1.20 (1.17-1.22)]. Case detection was highest among MSM but increased over time among all 3 groups. Conclusions: NG/CT case detection increased as testing expanded in the population. This supports a broad approach to NG/CT screening among persons living with HIV to decrease transmission and complications of NG/CT and of HIV.
引用
收藏
页码:409 / 416
页数:8
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