Synthesis and antiproliferative activity of unnatural enantiomers of 7-epi-goniofufurone and crassalactone C

被引：13

作者：

Popsavin, Velimir ^{[1
]}

Benedekovic, Goran ^{[1
]}

Sreco, Bojana ^{[1
]}

Popsavin, Mirjana ^{[1
]}

Francuz, Jovana ^{[1
]}

Kojic, Vesna ^{[2
]}

Bogdanovic, Gordana ^{[2
]}

机构：

[1] Univ Novi Sad, Fac Sci, Dept Chem, Novi Sad 21000, Serbia

[2] Inst Oncol Sremska Kamen, Sremska Kamenica 21204, Serbia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 19期

关键词：

styryl-lactones; stereocontrolled syntheses; D-xylose; 7-epigoniofufurone; crassalactone C; goniofufurone; unnatural enantiomers; antitumor agents;

D O I：

10.1016/j.bmcl.2008.08.093

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A facile synthesis of 7-epi-(-)-goniofufurone as well as the first synthesis of (-)-crassalactone C was achieved starting from D-xylose. A comparison of their in vitro antitumour activities with those observed for the corresponding naturally occurring enantiomers was provided. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：5178 / 5181

页数：4

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