The aim of this study was to detect the expression of beta-AR (Beta Adregenic Receptor) in Oral squamous cell carcinoma (OSCC), para-cancerous and normal oral mucosa and to investigate the relationship between the expression intensity and the characteristics and prognosis of oral cancer. 100 cases of OSCC were collected; 20 cases of paraneoplastic tissues and 10 cases of normal oral mucosa were taken as control. The expression of beta-AR was detected by immunohistochemical method and the average optical density determination using Image J software. Finally, the difference of beta-AR expression and the correlation with the clinicopathological factors were analyzed statistically. The expression of beta-AR in OSCC was higher than that in paracarcinoma and normal mucosa (P<0.01). The expression intensity of beta 1, beta 2-AR in preoperative lymph node metastasis group was higher than that in patients without lymph node metastasis (P<0.01). The expression intensity of beta 3-AR was not related to pathological grade and tumor size (P>0.05). beta 1 and beta 2-AR in early stage of OSCC were higher than those in early stage (P<0.05). Lymph node metastasis, recurrence, TNM clinical stage, and the expression intensity of beta 1-AR all had an effect on the cumulative survival rate. All the beta 1, 2, 3-AR were expressed in OSCC. beta 1 and beta 2-AR were involved in lymphatic metastasis and had influence on clinical staging. Metastasis, recurrence, TNM stage and expression of beta 1-AR had an effect on the cumulative survival rate of tumor. The expression of beta 3-AR in OSCC was not associated with the pathological grades and tumor growth.
机构:
Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP, BrazilUniv Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP, Brazil
Oliveira, Denise Tostes
Bravo-Calderon, Diego Mauricio
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP, BrazilUniv Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP, Brazil
Bravo-Calderon, Diego Mauricio
Lauand, Gustavo Amaral
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP, BrazilUniv Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP, Brazil
Lauand, Gustavo Amaral
Assao, Agnes
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP, BrazilUniv Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP, Brazil
Assao, Agnes
Suarez-Penaranda, Jose-Manuel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp, Dept Pathol & Forens Sci, Santiago De Compostela 15706, Galicia, Spain
Sch Med Santiago de Compostela, Santiago De Compostela 15706, Galicia, SpainUniv Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP, Brazil
Suarez-Penaranda, Jose-Manuel
Perez-Sayans, Mario
论文数: 0引用数: 0
h-index: 0
机构:
Clin Hosp Univ Santiago, Inst Res Santiago de Compostela IDIS, Fac Med & Dent, Santiago De Compostela 15782, A Coruna, SpainUniv Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP, Brazil
Perez-Sayans, Mario
Garcia-Garcia, Abel
论文数: 0引用数: 0
h-index: 0
机构:
Clin Hosp Univ Santiago, Inst Res Santiago de Compostela IDIS, Fac Med & Dent, Santiago De Compostela 15782, A Coruna, SpainUniv Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP, Brazil
Garcia-Garcia, Abel
Marana, Aparecido Nilceu
论文数: 0引用数: 0
h-index: 0
机构:
Sao Paulo State Univ UNESP, Fac Sci, Dept Comp, BR-17033360 Bauru, SP, BrazilUniv Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP, Brazil
Marana, Aparecido Nilceu
Nonogaki, Suely
论文数: 0引用数: 0
h-index: 0
机构:
Adolfo Lutz Inst, Div Pathol, BR-01246902 Sao Paulo, SP, BrazilUniv Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP, Brazil
Nonogaki, Suely
Pereira Lauris, Jose Roberto
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Bauru Sch Dent, Dept Community Dent, BR-17012901 Bauru, SP, BrazilUniv Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP, Brazil
Pereira Lauris, Jose Roberto
Kowalski, Luiz Paulo
论文数: 0引用数: 0
h-index: 0
机构:
AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, BR-01509010 Sao Paulo, SP, BrazilUniv Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP, Brazil
机构:
Sichuan Univ, W China Coll Stomatol, Dept Head & Neck Carcinoma, Chengdu 610064, Sichuan, Peoples R China
Sichuan Univ, State Key Lab Oral Dis, Sichuan, Peoples R ChinaSichuan Univ, W China Coll Stomatol, Dept Head & Neck Carcinoma, Chengdu 610064, Sichuan, Peoples R China
Zhao, D.
Pan, J.
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, W China Coll Stomatol, Dept Head & Neck Carcinoma, Chengdu 610064, Sichuan, Peoples R ChinaSichuan Univ, W China Coll Stomatol, Dept Head & Neck Carcinoma, Chengdu 610064, Sichuan, Peoples R China
Pan, J.
Li, X. Q.
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, State Key Lab Oral Dis, Sichuan, Peoples R ChinaSichuan Univ, W China Coll Stomatol, Dept Head & Neck Carcinoma, Chengdu 610064, Sichuan, Peoples R China
Li, X. Q.
Wang, X. Y.
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, W China Coll Stomatol, Dept Head & Neck Carcinoma, Chengdu 610064, Sichuan, Peoples R China
Sichuan Univ, State Key Lab Oral Dis, Sichuan, Peoples R ChinaSichuan Univ, W China Coll Stomatol, Dept Head & Neck Carcinoma, Chengdu 610064, Sichuan, Peoples R China
Wang, X. Y.
Tang, C.
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, W China Coll Stomatol, Dept Head & Neck Carcinoma, Chengdu 610064, Sichuan, Peoples R ChinaSichuan Univ, W China Coll Stomatol, Dept Head & Neck Carcinoma, Chengdu 610064, Sichuan, Peoples R China
Tang, C.
Xuan, M.
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, W China Coll Stomatol, Dept Head & Neck Carcinoma, Chengdu 610064, Sichuan, Peoples R ChinaSichuan Univ, W China Coll Stomatol, Dept Head & Neck Carcinoma, Chengdu 610064, Sichuan, Peoples R China