Expression of beta adrenergic receptor in oral squamous cell carcinoma and its significance to the prognosis

被引:0
|
作者
Dong, Hao [1 ,2 ]
Liao, Xian-Xiang [1 ]
Mai, Hua-Ming [1 ]
Zhou, Nuo [1 ]
Wang, Dai-You [1 ]
Peng, Jian-Bo [1 ]
Yang, Liang-Hui [1 ]
机构
[1] Guangxi Med Univ, Dept Oral & Maxillofacial Surg, Coll Stomatol, Nanning, Peoples R China
[2] Guangxi Zhuang Autonomous Reg Peoples Hosp, Dept Oral & Maxillofacial Surg, Nanning, Peoples R China
基金
中国国家自然科学基金;
关键词
Oral squamous cell carcinoma; beta-adrenergic receptor; lymph node; metastasis; prognosis; NEGATIVE BREAST-CANCER; BETA(2)-ADRENERGIC RECEPTOR; PANCREATIC-CANCER; OVARIAN-CANCER; PATHWAY; PROGRESSION; METASTASIS; SURVIVAL; NOREPINEPHRINE; PROLIFERATION;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The aim of this study was to detect the expression of beta-AR (Beta Adregenic Receptor) in Oral squamous cell carcinoma (OSCC), para-cancerous and normal oral mucosa and to investigate the relationship between the expression intensity and the characteristics and prognosis of oral cancer. 100 cases of OSCC were collected; 20 cases of paraneoplastic tissues and 10 cases of normal oral mucosa were taken as control. The expression of beta-AR was detected by immunohistochemical method and the average optical density determination using Image J software. Finally, the difference of beta-AR expression and the correlation with the clinicopathological factors were analyzed statistically. The expression of beta-AR in OSCC was higher than that in paracarcinoma and normal mucosa (P<0.01). The expression intensity of beta 1, beta 2-AR in preoperative lymph node metastasis group was higher than that in patients without lymph node metastasis (P<0.01). The expression intensity of beta 3-AR was not related to pathological grade and tumor size (P>0.05). beta 1 and beta 2-AR in early stage of OSCC were higher than those in early stage (P<0.05). Lymph node metastasis, recurrence, TNM clinical stage, and the expression intensity of beta 1-AR all had an effect on the cumulative survival rate. All the beta 1, 2, 3-AR were expressed in OSCC. beta 1 and beta 2-AR were involved in lymphatic metastasis and had influence on clinical staging. Metastasis, recurrence, TNM stage and expression of beta 1-AR had an effect on the cumulative survival rate of tumor. The expression of beta 3-AR in OSCC was not associated with the pathological grades and tumor growth.
引用
收藏
页码:10431 / 10440
页数:10
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