Humoral immune response in goats immunised with cathepsin L1, peroxiredoxin and Sm14 antigen and experimentally challenged with Fasciola hepatica

被引：30

作者：

Buffoni, L. ^{[1
]}

Martinez-Moreno, F. J. ^{[1
]}

Zafra, R. ^{[2
]}

Mendes, R. E. ^{[2
]}

Perez-Ecija, A. ^{[2
]}

Sekiya, M. ^{[3
]}

Mulcahy, G. ^{[3
]}

Perez, J. ^{[3
]}

Martinez-Moreno, A. ^{[1
]}

机构：

[1] Univ Cordoba, Fac Vet Med, Anim Hlth Dept Parasitol & Parasit Dis, Cordoba 14014, Spain

[2] Univ Cordoba, Fac Vet Med, Anat & Comparat Pathol Dept, Cordoba 14014, Spain

[3] Univ Coll Dublin, Coll Life Sci, Sch Agr Food Sci & Vet Med, Vet Sci Ctr, Dublin 4, Ireland

来源：

VETERINARY PARASITOLOGY | 2012年 / 185卷 / 2-4期

关键词：

Fasciola hepatica; Goats; Cathepsin L1; Peroxiredoxin; Sm14; L PROTEINASES; LIVER FLUKE; INFECTION; VACCINATION; CATTLE; SHEEP; PROTECTION; VACCINES; INDUCTION; PRODUCTS;

D O I：

10.1016/j.vetpar.2011.09.027

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The humoral immune response was analysed in goats immunised with FhCL1, FhPrx, Sm14, and experimentally challenged with Fasciola hepatica. All immunised animals developed significant levels of anti-fluke specific antibodies and those immunised with FhCL1 showed the highest antibody titre. After experimental infection, an increase in the antibody level was detected only in goats immunised with FhCL1. In the adjuvant-control animals, the experimental challenge induced significant production of specific antibodies against FhCL1, FhPrx and Sm14. While liver fluke specific humoral responses were seen in all groups, no significant protection in any of the vaccinated groups was found. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：315 / 321

页数：7

共 24 条

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