Diterpenes from the berries of Juniperus excelsa

被引：94
作者：
Topçu, G
Erenler, R
Çakmak, O
Johansson, CB
Çelik, C
Chai, HB
Pezzuto, JM
机构：
[1] TUBITAK, Marmara Res Ctr, Dept Chem, TR-41470 Gebze, Kocaeli, Turkey
[2] Gaziosmanpasa Univ, Fac Art & Sci, Dept Chem, TR-60100 Tokat, Turkey
[3] Univ Marmara, Fac Med, Dept Microbiol, Istanbul, Turkey
[4] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA
来源：
PHYTOCHEMISTRY | 1999年 / 50卷 / 07期
关键词：
Juniperus excelsa; Cupressaceae; berries; diterpenes; juniperexcelsic acid; sesquiterpene; cytotoxic; antituberculosis and antibacterial activity;
D O I：
10.1016/S0031-9422(98)00675-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
From the hexane extract of berries of Juniperus excelsa, one new and four known diterpenes were isolated besides a known sesquiterpene. The structures of the known diterpenes were identified as isopimaric, isocommunic, (-)ent-trans communic and sandracopimaric acids, along with the sesquiterpene 4a-hydroxycedrol and the new compound which was elucidated as 3 alpha-acetoxylabda-8(17), 13(16), 14-trien-19-oic acid (juniperexcelsic acid). Cytotoxic activity of the hexane extract was investigated against a panel of cell line and found highyl active against LNCaP, KB-V (+VLB) and KB-V (-VLB) cell lines. Furthermore, the hexane and methanol extracts, and the new compound were found to be moderately active against Mycobacterium tuberculosis. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：1195 / 1199
页数：5
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