Epigenetic biomarkers in epithelial ovarian cancer

被引:74
作者
Gloss, Brian S. [1 ]
Samimi, Goli [1 ,2 ]
机构
[1] Garvan Inst Med Res, Canc Res Program, Sydney, NSW, Australia
[2] Univ New S Wales, Fac Med, St Vincents Clin Sch, Sydney, NSW, Australia
基金
英国医学研究理事会;
关键词
High-grade serous ovarian cancer; Epigenetic biomarkers; ABERRANT PROMOTER METHYLATION; PROGRESSION-FREE SURVIVAL; GENE-EXPRESSION PROFILES; DNA METHYLATION; TUMOR-SUPPRESSOR; SEROUS CARCINOMA; CANDIDATE PRECURSOR; FALLOPIAN-TUBES; PLASMA DNA; HYPERMETHYLATION;
D O I
10.1016/j.canlet.2011.12.036
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Ovarian cancer is the most lethal gynecological malignancy and the 5th leading cause of cancer death in women. Women with ovarian cancer are typically diagnosed at late stage, when the cancer has spread into the peritoneal cavity and complete surgical removal is difficult. The 5-year survival time for patients diagnosed at this stage is 30%, in contrast to a 5-year survival of 90% for patients diagnosed at early stage. Cancer screening and early detection have the potential to greatly decrease the mortality and morbidity from cancer. The emerging field of epigenetics offers a valuable opportunity to identify cancer-specific DNA methylation changes that can be used in the clinic to improve early-stage diagnosis and better predict response in treated patients. To date, numerous DNA methylation aberrations have been identified in epithelial ovarian cancer; here we review some candidate genes and pathways with potential clinical utility as biomarkers for diagnosis and/or prognosis. It has become clear that even with the great promise of DNA methylation biomarkers in epithelial ovarian cancer, the identification of highly specific, sensitive and robust panels of markers and the standardization of analysis techniques are still required in order to improve detection, treatment and thus patient outcome. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:257 / 263
页数:7
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