Aplastic anemia in rural Thailand: Its association with grain farming and agricultural pesticide exposure

被引：32

作者：

Issaragrisil, S

Chansung, K

Kaufman, DW

Sirijirachai, J

Thamprasit, T

Young, NS

Anderson, T

Leaverton, PE

Piankijagum, A

Porapakkham, Y

Shapiro, S

Vannasaeng, S

Sompradeekul, S

Vuthivatanakul, T

Sriratanasatavorn, C

Yamcharoen, C

Laewsiri, P

Kittimongcolporn, S

Tepmongcol, K

Wongkongdej, R

Vejjapinand, R

Kiatvirakul, V

Kareng, K

Suvatte, V

Intaragumthornchai, T

Chancharunee, S

Prayoonwiwat, V

Seksan, P

Chuansumrit, A

Chinarat, V

Angkuravorakul, S

Atichartkarn, V

Chutipong, S

Fucharoen, S

Hathirat, P

Isarankura, P

Jetsrisuparb, A

Jootar, S

Kiatkachorntada, N

Kitkornpan, S

Laohavinij, S

Laosombat, V

Lekhakul, A

Mahasandana, C

Makornkaewkayoon, V

Nitiyanont, P

Pootrakul, P

Singhapan, K

Siritanaratanakul, N

Sonakul, D

机构：

[1] KHON KAEN UNIV,FAC MED,DEPT MED,KHON KAEN 40002,THAILAND

[2] BOSTON UNIV,SCH MED,SCH PUBL HLTH,SLOAN EPIDEMIOL UNIT,BROOKLINE,MA

[3] PRINCE SONGKLA UNIV,FAC MED,DEPT MED,SONGKHLA,THAILAND

[4] NHLBI,HEMATOL BRANCH,NIH,BETHESDA,MD 20892

来源：

AMERICAN JOURNAL OF PUBLIC HEALTH | 1997年 / 87卷 / 09期

关键词：

D O I：

10.2105/AJPH.87.9.1551

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objectives. A population-based cage-control study was conducted to elucidate the incidence and etiology of aplastic anemia in Thailand. Methods. Case patients and hospital control patients:were enrolled in three regions from 1989 to 1994; data were collected by interview. Results. Forty-six percent of 81 case patients and 19% of 295 control patients from Khonkaen were grain farmers (estimated relative risk [RR] = 2.7, 95% confidence interval [CI] = 1.4, 5.2). Sixteen percent of case patients and 6% of control patients used agricultural pesticides (estimated RR = 2.7, 95% CI = 1.1, 6.6). The association with grain farming remained among those not exposed to pesticides. In Songkla, 16% of 43 case patients and 2% of 181 control patients were grain farmers (crude RR estimate = 11, 95% CI = 3.4, 35). Conclusions. The relation. of aplastic anemia to grain farming may partly explain the high incidence of aplastic anemia in Thailand.

引用

页码：1551 / 1554

页数：4

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