Endothelial nitric oxide synthase in the microcirculation

被引：94

作者：

Shu, Xiaohong ^{[1
,2
]}

Keller, T. C. Stevenson ^{[2
,3
]}

Begandt, Daniela ^{[2
]}

Butcher, Joshua T. ^{[2
]}

Biwer, Lauren ^{[2
,3
]}

Keller, Alexander S. ^{[2
,3
,4
]}

Columbus, Linda ^{[5
]}

Isakson, Brant E. ^{[2
,3
]}

机构：

[1] Dalian Med Univ, Coll Pharm, Dalian 116044, Peoples R China

[2] Univ Virginia, Sch Med, Robert M Berne Cardiovasc Res Ctr, Charlottesville, VA 22908 USA

[3] Univ Virginia, Sch Med, Dept Mol Physiol & Biophys, Charlottesville, VA 22908 USA

[4] Univ Virginia, Sch Med, Dept Pharmacol, Charlottesville, VA 22908 USA

[5] Univ Virginia, Dept Chem, Charlottesville, VA USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2015年 / 72卷 / 23期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

Endothelial nitric oxide synthase; Nitric oxide; Endothelium; Microcirculation; RED-BLOOD-CELLS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; AUTOINHIBITORY CONTROL ELEMENT; SOLUBLE GUANYLATE-CYCLASE; SHEAR-STRESS; IN-VIVO; NO SYNTHASE; L-ARGININE; PLASMALEMMAL CAVEOLAE; ENOS PHOSPHORYLATION;

D O I：

10.1007/s00018-015-2021-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelial nitric oxide synthase (eNOS, NOS3) is responsible for producing nitric oxide (NO)-a key molecule that can directly (or indirectly) act as a vasodilator and anti-inflammatory mediator. In this review, we examine the structural effects of regulation of the eNOS enzyme, including post-translational modifications and subcellular localization. After production, NO diffuses to surrounding cells with a variety of effects. We focus on the physiological role of NO and NO-derived molecules, including microvascular effects on vessel tone and immune response. Regulation of eNOS and NO action is complicated; we address endogenous and exogenous mechanisms of NO regulation with a discussion of pharmacological agents used in clinical and laboratory settings and a proposed role for eNOS in circulating red blood cells.

引用

页码：4561 / 4575

页数：15

共 176 条

[1] The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome [J].