Imaging retina to study dementia and stroke

被引:201
作者
Cheung, Carol Yim-lui [1 ]
Ikram, M. Kamran [3 ,4 ,5 ]
Chen, Christopher [6 ,7 ]
Wong, Tien Yin [2 ,3 ]
机构
[1] Chinese Univ Hong Kong, Dept Ophthalmol & Visual Sci, Hong Kong, Hong Kong, Peoples R China
[2] Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore
[3] Natl Univ Singapore, Duke NUS Grad Med Sch, Singapore, Singapore
[4] Erasmus Univ, Med Ctr, Dept Neurol, Rotterdam, Netherlands
[5] Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands
[6] Natl Univ Hlth Syst, Memory Aging & Cognit Ctr, Singapore, Singapore
[7] Natl Univ Singapore, Dept Pharmacol, Singapore, Singapore
关键词
Retinal imaging; Retinal microvasculature; Retinal ganglion cell; Dementia; Alzheimer's disease; Stroke; Cerebrovascular disease; NERVE-FIBER LAYER; OPTICAL COHERENCE TOMOGRAPHY; MILD COGNITIVE IMPAIRMENT; SMALL VESSEL DISEASE; WHITE-MATTER LESIONS; MICROVASCULAR NETWORK ALTERATIONS; SCANNING LASER OPHTHALMOSCOPY; VASCULAR FRACTAL DIMENSION; GANGLION-CELL LAYER; ALZHEIMERS-DISEASE;
D O I
10.1016/j.preteyeres.2017.01.001
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
With increase in life expectancy, the number of persons suffering from common age-related brain diseases, including neurodegenerative (e.g., dementia) and cerebrovascular (e.g., stroke) disease is expected to rise substantially. As current neuro-imaging modalities such as magnetic resonance imaging may not be able to detect subtle subclinical changes (resolution <100-500 gm) in dementia and stroke, there is an urgent need for other complementary techniques to probe the pathophysiology of these diseases. The retina-due to its anatomical, embryological and physiological similarities with the brain-offers a unique and accessible "window" to study correlates and consequences of subclinical pathology in the brain. Retinal components such as the microvasculature and retinal ganglion cell axons can now be visualized non-invasively using different retinal imaging techniques e.g., ocular fundus photography and optical coherence tomography. Advances in retinal imaging may provide new and potentially important insights into cerebrovascular neurodegenerative processes in addition to what is currently possible with neuro-imaging. In this review, we present an overview of the current literature on the application of retinal imaging in the study of dementia and stroke. We discuss clinical implications of these studies, novel state-of-the-art retinal imaging techniques and future directions aimed at evaluating whether retinal imaging can be an additional investigation tool in the study of dementia and stroke. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码:89 / 107
页数:19
相关论文
共 217 条
[1]   Assessment of Accuracy and Precision of Quantification of Ultra-Widefield Images [J].
Aboshiha, Jonathan ;
Dubis, Adam M. ;
van der Spuy, Jacqueline ;
Nishiguchi, Koji M. ;
Cheeseman, Edward W. ;
Ayuso, Carmen ;
Ehrenberg, Miriam ;
Simonelli, Francesca ;
Bainbridge, James W. ;
Michaelides, Michel .
OPHTHALMOLOGY, 2015, 122 (04) :864-866
[2]   Improved Automated Detection of Diabetic Retinopathy on a Publicly Available Dataset Through Integration of Deep Learning [J].
Abramoff, Michael David ;
Lou, Yiyue ;
Erginay, Ali ;
Clarida, Warren ;
Amelon, Ryan ;
Folk, James C. ;
Niemeijer, Meindert .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (13) :5200-5206
[3]   RETINAL, CEREBRAL AND SYSTEMIC ARTERIOSCLEROSIS - A HISTOPATHOLOGIC STUDY [J].
ALPERS, BJ ;
FORSTER, FM ;
HERBUT, PA .
ARCHIVES OF NEUROLOGY AND PSYCHIATRY, 1948, 60 (05) :440-456
[4]  
Alzheimer's Association, 2016, Alzheimers Dement, V12, P459
[5]   Characterization of β amyloid assemblies in drusen:: the deposits associated with aging and age-related macular degeneration [J].
Anderson, DH ;
Talaga, KC ;
Rivest, AJ ;
Barron, E ;
Hageman, GS ;
Johnson, LV .
EXPERIMENTAL EYE RESEARCH, 2004, 78 (02) :243-256
[6]   Retinal alterations in mild cognitive impairment and Alzheimer's disease: an optical coherence tomography study [J].
Ascaso, Francisco J. ;
Cruz, Nancy ;
Modrego, Pedro J. ;
Lopez-Anton, Raul ;
Santabarbara, Javier ;
Pascual, Luis F. ;
Lobo, Antonio ;
Cristobal, Jose A. .
JOURNAL OF NEUROLOGY, 2014, 261 (08) :1522-1530
[7]   Retinal microvascular signs, cognitive function, and dementia in older persons - The cardiovascular health study [J].
Baker, Michelle L. ;
Larsen, Emily K. Marino ;
Kuller, Lewis H. ;
Klein, Ronald ;
Klein, Barbara E. K. ;
Siscovick, David S. ;
Bernick, Charles ;
Manolio, Teri A. ;
Wong, Tien Yin .
STROKE, 2007, 38 (07) :2041-2047
[8]   Retinopathy and Lobar Intracerebral Hemorrhage Insights Into Pathogenesis [J].
Baker, Michelle L. ;
Hand, Peter J. ;
Wong, Tien Y. ;
Liew, Gerald ;
Rochtchina, Elena ;
Mitchell, Paul ;
Lindley, Richard I. ;
Hankey, Graeme J. ;
Wang, Jie Jin .
ARCHIVES OF NEUROLOGY, 2010, 67 (10) :1224-1230
[9]   Differential Associations of Cortical and Subcortical Cerebral Atrophy With Retinal Vascular Signs in Patients With Acute Stroke [J].
Baker, Michelle L. ;
Wang, Jie Jin ;
Liew, Gerald ;
Hand, Peter J. ;
De Silva, Deidre A. ;
Lindley, Richard I. ;
Mitchell, Paul ;
Wong, Meng-Cheong ;
Rochtchina, Elena ;
Wong, Tien Y. ;
Wardlaw, Joanna M. ;
Hankey, Graeme J. .
STROKE, 2010, 41 (10) :2143-2150
[10]   Retinal Microvascular Signs May Provide Clues to the Underlying Vasculopathy in Patients With Deep Intracerebral Hemorrhage [J].
Baker, Michelle L. ;
Hand, Peter J. ;
Liew, Gerald ;
Wong, Tien Y. ;
Rochtchina, Elena ;
Mitchell, Paul ;
Lindley, Richard I. ;
Hankey, Graeme J. ;
Wang, Jie Jin .
STROKE, 2010, 41 (04) :618-623