A near-infrared fluorescence dye for sensitive detection of hydrogen sulfide in serum

被引：17
作者：
Wu, Xuanjun [1 ,2 ]
Shi, Jiaqi [1 ,2 ]
Yang, Liu [1 ,2 ]
Han, Jiahuai [3 ,4 ]
Han, Shoufa [1 ,2 ]
机构：
[1] Xiamen Univ, Coll Chem & Chem Engn, Dept Biol Chem, Key Lab Chem Biol Fujian Prov,MOE Key Lab Spectro, Xiamen 361005, Peoples R China
[2] Xiamen Univ, Innovat Ctr Cell Biol, Xiamen 361005, Peoples R China
[3] State Ocean Adm, Inst Oceanog 3, Key Lab Marine Genet Resources, Xiamen 361005, Peoples R China
[4] Xiamen Univ, Sch Life Sci, Innovat Ctr Cell Biol, State Key Lab Cellular Stress Biol, Xiamen 361005, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 01期
基金：
美国国家科学基金会;
关键词：
Hydrogen sulfide; Cyanine dye; Serum; Mitochondria; Bioimaging; Near-infrared; PROBE; SENSOR; STATE;
D O I：
10.1016/j.bmcl.2013.11.016
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cy-Cl, a cationic near-infrared cyanine dye, readily reacts with hydrogen sulfide (H2S) via nucleophilic thiolation to give dose-dependent 'turn-off' fluorescence and colorimetric read-out, allowing selective detection of low levels of H2S in serum and imaging of mitochondrial H2S in living cells. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：314 / 316
页数：3
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