Analysis of 30 Genes (355 SNPS) Related to Energy Homeostasis for Association with Adiposity in European-American and Yup'ik Eskimo Populations

被引：13

作者：

Chung, Wendy K. ^{[1
,2
]}

Patki, Amit ^{[3
]}

Matsuoka, Naoki ^{[1
,2
]}

Boyer, Bert B. ^{[4
]}

Liu, Nianjun ^{[3
]}

Musani, Solomon K. ^{[3
]}

Goropashnaya, Anna V. ^{[4
]}

Tan, Perciliz L. ^{[5
]}

Katsanis, Nicholas ^{[5
]}

Johnson, Stephen B. ^{[1
]}

Gregersen, Peter K. ^{[6
]}

Allison, David B. ^{[3
]}

Leibel, Rudolph L. ^{[1
,2
]}

Tiwari, Hemant K. ^{[3
]}

机构：

[1] Columbia Univ, Med Ctr, New York, NY 10032 USA

[2] Naomi Berrie Diabet Ctr, New York, NY USA

[3] Univ Alabama, Birmingham, AL USA

[4] Univ Alaska Fairbanks, Fairbanks, AK USA

[5] Johns Hopkins Univ, Baltimore, MD USA

[6] Feinstein Inst Med Res, Manhasset, NY USA

来源：

HUMAN HEREDITY | 2009年 / 67卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Obesity; Body composition; Body mass index; Candidate gene; Ghrelin; BODY-MASS INDEX; GHRELIN GENE; EXTREME GROUPS; HUMAN OBESITY; LEU72MET POLYMORPHISM; LINKAGE PHASE; US ADULTS; CHILDREN; ADOLESCENTS; PREVALENCE;

D O I：

10.1159/000181158

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Objective: Human adiposity is highly heritable, but few of the genes that predispose to obesity in most humans are known. We tested candidate genes in pathways related to food intake and energy expenditure for association with measures of adiposity. Methods: We studied 355 genetic variants in 30 candidate genes in 7 molecular pathways related to obesity in two groups of adult subjects: 1,982 unrelated European Americans living in the New York metropolitan area drawn from the extremes of their body mass index (BMI) distribution and 593 related Yup'ik Eskimos living in rural Alaska characterized for BMI, body composition, waist circumference, and skin fold thicknesses. Data were analyzed by using a mixed model in conjunction with a false discovery rate (FDR) procedure to correct for multiple testing. Results: After correcting for multiple testing, two single nucleotide polymorphisms (SNPs) in Ghrelin (GHRL) (rs35682 and rs35683) were associated with BMI in the New York European Americans. This association was not replicated in the Yup'ik participants. There was no evidence for gene x gene interactions among genes within the same molecular pathway after adjusting for multiple testing via FDR control procedure. Conclusion: Genetic variation in GHRL may have a modest impact on BMI in European Americans. Copyright (C) 2008 S. Karger AG, Basel

引用

页码：193 / 205

页数：13

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