Magnetic molecularly imprinted polymer for the selective extraction of sildenafil, vardenafil and their analogs from herbal medicines

被引：34
作者：
Chen, Fang-Fang [1 ,2 ,3 ]
Xie, Xiao-Yu [1 ,2 ,3 ]
Shi, Yan-Ping [1 ,2 ]
机构：
[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwest Plant Resources, Lanzhou 730000, Peoples R China
[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China
[3] Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
来源：
TALANTA | 2013年 / 115卷
基金：
中国国家自然科学基金;
关键词：
Magnetic molecularly imprinted polymers; Herbal medicines; Phosphodiesterase type-5 inhibitors; Sildenafil; Solid phase extraction; SYNTHETIC PHOSPHODIESTERASE-5 INHIBITORS; CHROMATOGRAPHY-MASS SPECTROMETRY; SOLID-PHASE EXTRACTION; STRUCTURE ELUCIDATION; DIETARY-SUPPLEMENTS; LIQUID-CHROMATOGRAPHY; ERECTILE DYSFUNCTION; DESIGNER DRUG; TADALAFIL; NANOPARTICLES;
D O I：
10.1016/j.talanta.2013.06.009
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The successfully developed magnetic molecularly imprinted polymers (MMIPs) toward six synthetic phosphodiesterase type-5 (PDE-5) inhibitors were described. Sildenafil was used as template for the preparation of MMIPs using superparamagnetic core shell nanoparticle as supporter. The obtained MMIPs were characterized using transmission electron microscope, Fourier transform infrared, X-ray diffraction, and vibrating sample magnetometer. High performance liquid chromatography (HPLC) with diode array detector (DAD) was used for the analysis of target analytes. The application of MMIPs as selective sorbent in the cleanup of herbal medicine samples prior to HPLC offered simple sample preparation. The adsorption capacity and selectivity of prepared MMIPs and magnetic non-molecularly imprinted polymers were investigated. The binding isotherms were obtained for sildenafil and fitted by Freundlich isotherm model. Structurally similar compound of sildenafil and a reference compound protocatechuic acid were used for investing the selective recognition of MMIPs. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：482 / 489
页数：8
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