Diarylprolinol-Mediated Asymmetric Direct Cross-Aldol Reaction of α,β-Unsaturated Aldehyde as an Electrophilic Aldehyde

被引：6

作者：

Hayashi, Yujiro ^{[1
]}

Nagai, Kaito ^{[1
]}

Umemiya, Shigenobu ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Sci, Dept Chem, Aoba Ku, 6-3 Aramaki Aza Aoba, Sendai, Miyagi 9808578, Japan

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2019年 / 14卷 / 23期

基金：

日本学术振兴会;

关键词：

aldehydes; aldol reaction; allyl alcohol; asymmetric synthesis; organocatalysis; WATER;

D O I：

10.1002/asia.201901236

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The diarylprolinol-mediated asymmetric direct cross-aldol reaction of alpha,beta-unsaturated aldehyde as an electrophilic aldehyde was developed. The reaction becomes accelerated by an acid when a carbonyl group is introduced at the gamma-position of the alpha,beta-unsaturated aldehyde. Synthetically useful gamma,delta-unsaturated beta-hydroxy aldehydes were obtained with highanti-selectivity and excellent enantioselectivity.

引用

收藏

页码：4146 / 4149

页数：4

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