Synthesis of non-nucleosides:: 7-and 1,3-substituents of new pyrrolo[2,3-d]pyrimidin-4-ones on antiviral activity

被引：9

作者：

Hilmy, KMH ^{[1
]}

机构：

[1] Minoufiya Univ, Fac Sci, Dept Chem, Shibin Al Kawm, Egypt

来源：

ARCHIV DER PHARMAZIE | 2006年 / 339卷 / 04期

关键词：

pyrrolo[2,3-d]pyrimidin-4-ones; synthesis; MIC; antiviral activity against HSV-II;

D O I：

10.1002/ardp.200500162

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of non-nucleosides 9-47 were synthesized. Compounds 1-4 were reacted with formic acid (85%) to afford compounds 3-8. Then, the latter compounds were reacted with alkyl halides a-f (2-bromopropane, 2-bromobutane, benzyl bromide, benzyl chloromethyl ether, chloromethyl ethyl ether, phenacyl bromide) in the presence of NaH in dry DMF to give the desired compounds 9-47, which were evaluated for activity against herpes simplex virus type-II (HSV-II).

引用

页码：174 / 181

页数：8

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