PASSIVE IMMUNOTHERAPY FOR ALZHEIMER'S DISEASE: WHAT HAVE WE LEARNED, AND WHERE ARE WE HEADED?

被引：17

作者：

Aisen, P. S. ^{[1
]}

Vellas, B. ^{[2
]}

机构：

[1] Univ Calif San Diego, Alzheimers Dis Collaborat Study, La Jolla, CA 92093 USA

[2] Univ Toulouse 3, INSERM, UMR 1027, Univ Toulouse,CHU Toulouse, F-31062 Toulouse, France

来源：

JOURNAL OF NUTRITION HEALTH & AGING | 2013年 / 17卷 / 01期

关键词：

D O I：

10.1007/s12603-013-0001-3

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

引用

页码：49 / 50

页数：2

共 12 条

[1] An Effector-Reduced Anti-β-Amyloid (Aβ) Antibody with Unique Aβ Binding Properties Promotes Neuroprotection and Glial Engulfment of Aβ [J].

Adolfsson, Oskar ;

Pihlgren, Maria ;

Toni, Nicolas ;

Varisco, Yvan ;

Buccarello, Anna Lucia ;

Antoniello, Katia ;

Lohmann, Sophie ;

Piorkowska, Kasia ;

Gafner, Valerie ;

Atwal, Jasvinder K. ;

Maloney, Janice ;

Chen, Mark ;

Gogineni, Alvin ;

Weimer, Robby M. ;

Mortensen, Deborah L. ;

Friesenhahn, Michel ;

Ho, Carole ;

Paul, Robert ;

Pfeifer, Andrea ;

Muhs, Andreas ;

Watts, Ryan J. .

JOURNAL OF NEUROSCIENCE, 2012, 32 (28) :9677-9689

[2] Colombia at the centre of preclinical AD research [J].

不详 .

LANCET NEUROLOGY, 2012, 11 (07) :567-567

[3] Safety and biomarker effects of Solanezumab in patients with Alzheimer's disease [J].

Farlow, Martin ;

Amold, Steven E. ;

van Dyck, Christopher H. ;

Aisen, Paul S. ;

Snider, B. Joy ;

Porsteinsson, Anton P. ;

Friedrich, Stuart ;

Dean, Robert A. ;

Gonzales, Celedon ;

Sethuraman, Gopalan ;

DeMattos, Ronald B. ;

Mohs, Richard ;

Paul, Steven M. ;

Siemers, Eric R. .

ALZHEIMERS & DEMENTIA, 2012, 8 (04) :261-271

[4] Correlative memory deficits, A beta elevation, and amyloid plaques in transgenic mice [J].

Hsiao, K ;

Chapman, P ;

Nilsen, S ;

Eckman, C ;

Harigaya, Y ;

Younkin, S ;

Yang, FS ;

Cole, G .

SCIENCE, 1996, 274 (5284) :99-102

[5] Mechanism of Amyloid Removal in Patients With Alzheimer Disease Treated With Gantenerumab [J].

Ostrowitzki, Susanne ;

Deptula, Dennis ;

Thurfjell, Lennart ;

Barkhof, Frederik ;

Bohrmann, Bernd ;

Brooks, David J. ;

Klunk, William E. ;

Ashford, Elizabeth ;

Yoo, Kisook ;

Xu, Zhi-Xin ;

Loetscher, Hansruedi ;

Santarelli, Luca .

ARCHIVES OF NEUROLOGY, 2012, 69 (02) :198-207

[6] 11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study [J].

Rinne, Juha O. ;

Brooks, David J. ;

Rossor, Martin N. ;

Fox, Nick C. ;

Bullock, Roger ;

Klunk, William E. ;

Mathis, Chester A. ;

Blennow, Kaj ;

Barakos, Jerome ;

Okello, Aren A. ;

de Llano, Sofia Rodriguez Martinez ;

Liu, Enchi ;

Koller, Martin ;

Gregg, Keith M. ;

Schenk, Dale ;

Black, Ronald ;

Grundman, Michael .

LANCET NEUROLOGY, 2010, 9 (04) :363-372

[7] A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease [J].

Salloway, S. ;

Sperling, R. ;

Gilman, S. ;

Fox, N. C. ;

Blennow, K. ;

Raskind, M. ;

Sabbagh, M. ;

Honig, L. S. ;

Doody, R. ;

van Dyck, C. H. ;

Mulnard, R. ;

Barakos, J. ;

Gregg, K. M. ;

Liu, E. ;

Lieberburg, I. ;

Schenk, D. ;

Black, R. ;

Grundman, M. .

NEUROLOGY, 2009, 73 (24) :2061-2070

[8] Immunization with amyloid-β attenuates Alzheimer disease-like pathology in the PDAPP mouse [J].

Schenk, D ;

Barbour, R ;

Dunn, W ;

Gordon, G ;

Grajeda, H ;

Guido, T ;

Hu, K ;

Huang, JP ;

Johnson-Wood, K ;

Khan, K ;

Kholodenko, D ;

Lee, M ;

Liao, ZM ;

Lieberburg, I ;

Motter, R ;

Mutter, L ;

Soriano, F ;

Shopp, G ;

Vasquez, N ;

Vandevert, C ;

Walker, S ;

Wogulis, M ;

Yednock, T ;

Games, D ;

Seubert, P .

NATURE, 1999, 400 (6740) :173-177

[9] Amyloid-β immunotherapy for Alzheimer's disease:: the end of the beginning [J].

Schenk, D .

NATURE REVIEWS NEUROSCIENCE, 2002, 3 (10) :824-828

[10] Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis [J].

Sperling, Reisa ;

Salloway, Stephen ;

Brooks, David J. ;

Tampieri, Donatella ;

Barakos, Jerome ;

Fox, Nick C. ;

Raskind, Murray ;

Sabbagh, Marwan ;

Honig, Lawrence S. ;

Porsteinsson, Anton P. ;

Lieberburg, Ivan ;

Arrighi, H. Michael ;

Morris, Kristen A. ;

Lu, Yuan ;

Liu, Enchi ;

Gregg, Keith M. ;

Brashear, H. Robert ;

Kinney, Gene G. ;

Black, Ronald ;

Grundman, Michael .

LANCET NEUROLOGY, 2012, 11 (03) :241-249

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