Synthesis and Biological Activity of Several Modified 5α-Androstanolone Derivatives

被引：5

作者：

Nadaraia, N. Sh. ^{[1
]}

Barbakadze, N. N. ^{[1
]}

Kakhabrishvili, M. L. ^{[1
]}

Sylla, B. ^{[2
]}

Pichette, A. ^{[2
]}

Makhmudov, U. S. ^{[3
]}

机构：

[1] Tbilisi State Med Univ, I Kutateladze Inst Pharmacochem, Tbilisi 0159, Georgia

[2] Univ Quebec Chicoutimi, LASEVE, Chicoutimi, PQ G7H 2B1, Canada

[3] Acad Sci Uzbek, S Yu Yunusov Inst Chem Plant Subst, Tashkent, Uzbekistan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2018年 / 54卷 / 02期

基金：

美国国家科学基金会;

关键词：

antiviral activity; epiandrosterone; modification; phenylacetic acid; hydrazones; pyrazolines; PHENYLACETIC ACID; STEROIDS; AUXIN;

D O I：

10.1007/s10600-018-2330-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several new N-containing epiandrosterone derivatives modified by phenylacetic acid chloride were synthesized for biological activity studies. Compounds with antiviral activity were discovered among them and 3 beta-hydroxy-1'-aryl-3'-methyl-5'-androstano[17,16-d]pyrazolines prepared by us earlier.

引用

页码：310 / 314

页数：5

共 15 条

[1] Green synthesis, biochemical and quantum chemical studies of steroidal oximes [J].

Alam, Mahboob ;

Lee, Dong-Ung .

KOREAN JOURNAL OF CHEMICAL ENGINEERING, 2015, 32 (06) :1142-1150

[2]

[Anonymous], 1996, PROGRAM ABSORPTION C

[3]

[Anonymous], 2009, OXF DIFFR CRYSAPLISP

[4]

[Anonymous], ASS ANT ACT RESP BIO

[5] Synthesis and evaluation of some steroidal oximes as cytotoxic agents: Structure/activity studies (I) [J].

Cui, Jian-Guo ;

Fan, Lei ;

Huang, Li-Liang ;

Liu, Hong-Li ;

Zhou, Ai-Min .

STEROIDS, 2009, 74 (01) :62-72

[6] Synthesis and antiproliferative activity of some steroidal thiosemicarbazones, semicarbazones and hydrozones [J].

Gan, Chunfang ;

Cui, Jianguo ;

Su, Shaoyang ;

Lin, Qifu ;

Jia, Linyi ;

Fan, Lianghua ;

Huang, Yanmin .

STEROIDS, 2014, 87 :99-107

[7] Discovery of novel isatin-dehydroepiandrosterone conjugates as potential anticancer agents [J].

Ke, Shaoyong ;

Shi, Liqiao ;

Yang, Ziwen .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (20) :4628-4631

[8] AUXIN ACTIVITY OF PHENYLACETIC ACID IN TISSUE-CULTURE [J].

LEUBA, V ;

LETOURNEAU, D .

JOURNAL OF PLANT GROWTH REGULATION, 1990, 9 (02) :71-76

[9] Synthesis and Antiviral Activity of Several N-Containing 5α-STEROIDS [J].

Nadaraia, N. Sh. ;

Onashvili, E. O. ;

Kakhabrishvili, M. L. ;

Barbakadze, N. N. ;

Sylla, B. ;

Pichette, A. .

CHEMISTRY OF NATURAL COMPOUNDS, 2016, 52 (05) :853-855

[10] Synthesis of Several 5α-Androstano[17,16-d]Pyrazolines from Tigogenin [J].

Nadaraia, N. Sh. ;

Kakhabrishvili, M. L. ;

Onashvili, E. O. ;

Barbakadze, N. N. ;

Getia, M. Z. ;

Pichette, A. ;

Sikharulidze, M. I. ;

Makhmudov, U. S. .

CHEMISTRY OF NATURAL COMPOUNDS, 2014, 50 (06) :1024-1028

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