Dextran based amphiphilic nano-hybrid hydrogel system incorporated with curcumin and cerium oxide nanoparticles for wound healing

被引:102
作者
Andrabi, Syed Muntazir [1 ,2 ,4 ]
Majumder, S. [4 ,5 ]
Gupta, Kailash Chand [2 ,6 ]
Kumar, Ashok [1 ,2 ,3 ]
机构
[1] Indian Inst Technol Kanpur, Biomat & Tissue Engn Grp, Dept Biol Sci & Bioengn, Kanpur 208016, Uttar Pradesh, India
[2] Indian Inst Technol Kanpur, Ctr Environm Sci & Engn, Kanpur 208016, Uttar Pradesh, India
[3] Indian Inst Technol Kanpur, Ctr Nanosci, Kanpur 208016, Uttar Pradesh, India
[4] Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida 201310, UP, India
[5] Mahatma Gandhi Cent Univ, Motihari 845401, Bihar, India
[6] CSIR, Inst Genom & Integrat Biol, Delhi Univ Campus,Mall Rd, Delhi 110007, India
关键词
Nanoparticles; Wound healing; Curcumin; Cerium oxide; Antioxidant; Amphiphilic; DRUG-DELIVERY; IN-VITRO; ANTIOXIDANT; SCAFFOLDS; CHITOSAN; GELATIN; ANTIBACTERIAL; ALGINATE; GROWTH; POLYSACCHARIDES;
D O I
10.1016/j.colsurfb.2020.111263
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
During injury or diseased condition, wound dressing fails to properly integrate or repair the tissue and restore its function due to various factors like poor bioavailability, systemic delivery of hydrophobic drugs and elevated levels of reactive oxygen species. Here, we fabricated a novel nano-hybrid hydrogel system, based-on gelatin and oxidized dextran, embedded with nano-formulation of curcumin and cerium oxide, dispersed by physical interaction within the hydrogel. The curcumin was entrapped in amphiphilic alkylated-dextran nanoparticles to enhance its bioavailability and release at the injured site while cerium oxide nanoparticles were used without any additional processing. The hydrogel was characterized for various properties and demonstrated a controlled and prolonged drug release (similar to 63 % in 108 h), accelerated cell migration besides providing a highly significant antioxidant and in-vivo anti-inflammatory activity (similar to 39 %). The preliminary study suggests that this hybrid system can significantly promote wound healing and the potential to become an ideal wound dressing.
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页数:15
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