Functional connectivity during masked and unmasked face emotion processing in bipolar disorder

被引：7

作者：

Tseng, Wan-Ling ^{[1
]}

Thomas, Laura A. ^{[2
]}

Harkins, Elizabeth ^{[1
]}

Stoddard, Joel ^{[1
]}

Zarate, Carlos A., Jr. ^{[3
]}

Pine, Daniel S. ^{[1
]}

Leibenluft, Ellen ^{[1
]}

Brotman, Melissa A. ^{[1
]}

机构：

[1] NIMH, Emot & Dev Branch, NIH, Dept Hlth & Human Serv, Bldg 15,Room 208,15K North Dr, Bethesda, MD 20892 USA

[2] Vet Affairs Med Ctr, War Related Illness & Injury Study Ctr, Washington, DC USA

[3] NIMH, Expt Therapeut & Pathophysiol Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2016年 / 258卷

基金：

美国国家卫生研究院;

关键词：

Bipolar disorder; Functional neuroimaging; Backward masking; Functional connectivity; Face emotion processing; SEVERE MOOD DYSREGULATION; PREFRONTAL CORTEX; AMYGDALA RESPONSE; RATING-SCALE; ANGRY FACES; FMRI; DEPRESSION; YOUTH; NEUROANATOMY; METAANALYSIS;

D O I：

10.1016/j.pscychresns.2016.10.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Little is known regarding the neural connectivity and correlates during automatic, unconscious face emotion processing in individuals with bipolar disorder (BD). In this study, 14 adults with BD and 14 healthy volunteers (HV) underwent fMRI scanning while completing an affective priming task with unconsciously perceived and consciously perceived faces (angry, happy, neutral, blank oval). We found that, regardless of awareness level and emotion types, BD patients exhibited diminished functional connectivity between amygdala and ventromedial prefrontal cortex (vmPFC) compared to HV. This connectivity finding is present in the absence of activation differences in amygdala. In addition, in medial frontal gyrus, BD patients displayed greater activation while HV displayed less activation to angry and neutral faces compared to blank ovals. These results suggest that aberrant amygdala-vmPFC connectivity and neural dysfunction in areas implicated in appraisal and expression of emotions (medial frontal gyrus) may be the pathophysiological correlates of emotional processing in BD regardless of awareness level.

引用

页码：1 / 9

页数：9

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