Functional connectivity during masked and unmasked face emotion processing in bipolar disorder

被引:7
作者
Tseng, Wan-Ling [1 ]
Thomas, Laura A. [2 ]
Harkins, Elizabeth [1 ]
Stoddard, Joel [1 ]
Zarate, Carlos A., Jr. [3 ]
Pine, Daniel S. [1 ]
Leibenluft, Ellen [1 ]
Brotman, Melissa A. [1 ]
机构
[1] NIMH, Emot & Dev Branch, NIH, Dept Hlth & Human Serv, Bldg 15,Room 208,15K North Dr, Bethesda, MD 20892 USA
[2] Vet Affairs Med Ctr, War Related Illness & Injury Study Ctr, Washington, DC USA
[3] NIMH, Expt Therapeut & Pathophysiol Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA
基金
美国国家卫生研究院;
关键词
Bipolar disorder; Functional neuroimaging; Backward masking; Functional connectivity; Face emotion processing; SEVERE MOOD DYSREGULATION; PREFRONTAL CORTEX; AMYGDALA RESPONSE; RATING-SCALE; ANGRY FACES; FMRI; DEPRESSION; YOUTH; NEUROANATOMY; METAANALYSIS;
D O I
10.1016/j.pscychresns.2016.10.006
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Little is known regarding the neural connectivity and correlates during automatic, unconscious face emotion processing in individuals with bipolar disorder (BD). In this study, 14 adults with BD and 14 healthy volunteers (HV) underwent fMRI scanning while completing an affective priming task with unconsciously perceived and consciously perceived faces (angry, happy, neutral, blank oval). We found that, regardless of awareness level and emotion types, BD patients exhibited diminished functional connectivity between amygdala and ventromedial prefrontal cortex (vmPFC) compared to HV. This connectivity finding is present in the absence of activation differences in amygdala. In addition, in medial frontal gyrus, BD patients displayed greater activation while HV displayed less activation to angry and neutral faces compared to blank ovals. These results suggest that aberrant amygdala-vmPFC connectivity and neural dysfunction in areas implicated in appraisal and expression of emotions (medial frontal gyrus) may be the pathophysiological correlates of emotional processing in BD regardless of awareness level.
引用
收藏
页码:1 / 9
页数:9
相关论文
共 49 条
[1]   Amygdala - frontal connectivity during emotion regulation [J].
Banks, Sarah J. ;
Eddy, Kamryn T. ;
Angstadt, Mike ;
Nathan, Pradeep J. ;
Phan, K. Luan .
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2007, 2 (04) :303-312
[2]   Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala-anterior paralimbic neural system [J].
Blond, Benjamin N. ;
Fredericks, Carolyn A. ;
Blumberg, Hilary P. .
BIPOLAR DISORDERS, 2012, 14 (04) :340-355
[3]   Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands [J].
Brotman, M. A. ;
Tseng, W. -L. ;
Olsavsky, A. K. ;
Fromm, S. J. ;
Muhrer, E. J. ;
Rutenberg, J. G. ;
Deveney, C. M. ;
Adleman, N. E. ;
Zarate, C. A., Jr. ;
Pine, D. S. ;
Leibenluft, E. .
PSYCHOLOGICAL MEDICINE, 2014, 44 (08) :1639-1651
[4]  
Carter Cameron S, 2016, Biol Psychiatry Cogn Neurosci Neuroimaging, V1, P99, DOI 10.1016/j.bpsc.2016.01.005
[5]   A quantitative meta-analysis of fMRI studies in bipolar disorder [J].
Chen, Chi-Hua ;
Suckling, John ;
Lennox, Belinda R. ;
Ooi, Cinly ;
Bullmore, Ed T. .
BIPOLAR DISORDERS, 2011, 13 (01) :1-15
[6]   A comparison of statistical methods for detecting context-modulated functional connectivity in fMRI [J].
Cisler, Josh M. ;
Bush, Keith ;
Steele, J. Scott .
NEUROIMAGE, 2014, 84 :1042-1052
[7]  
Cox R. W., 2016, 065862 BIORXIV
[8]   AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages [J].
Cox, RW .
COMPUTERS AND BIOMEDICAL RESEARCH, 1996, 29 (03) :162-173
[9]   Amygdala Functional Connectivity in Young Women with Borderline Personality Disorder [J].
Cullen, Kathryn R. ;
Vizueta, Nathalie ;
Thomas, Kathleen M. ;
Han, Georges J. ;
Lim, Kelvin O. ;
Camchong, Jazmin ;
Mueller, Bryon A. ;
Bell, Christopher H. ;
Heller, Monika D. ;
Schulz, S. Charles .
BRAIN CONNECTIVITY, 2011, 1 (01) :61-71
[10]   Masked facial affect priming is associated with therapy response in clinical depression [J].
Dannlowski, Udo ;
Kersting, Anette ;
Donges, Uta-Susan ;
Lalee-Mentzel, Judith ;
Arolt, Volker ;
Suslow, Thomas .
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2006, 256 (04) :215-221