CTCF and CTCFL in cancer

被引：57

作者：

Debaugny, Roxanne E. ^{[1
]}

Skok, Jane A. ^{[1
,2
]}

机构：

[1] New York Univ Langone Hlth, Dept Pathol, New York, NY 10016 USA

[2] NYU, Sch Med, Laura & Isaac Perlmutter Canc Ctr, New York, NY 10016 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2020年 / 61卷

关键词：

DNA METHYLATION; TRANSCRIPTION FACTOR; GENETIC ALTERATIONS; BORIS; MUTATIONS; BINDING; EXPRESSION; GENOME; BREAST; DOMAINS;

D O I：

10.1016/j.gde.2020.02.021

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

CTCF plays a key role in organizing chromatin into TAD structures but it can also function as a transcription factor. CTCFL (CTCF-like), the paralog of CTCF, is normally transiently expressed in pre-meiotic male germ cells together with ubiquitously expressed CTCF. It plays a unique role in spermatogenesis by regulating expression of testis-specific genes. Genetic alterations in CTCF and its paralog CTCFL have both been found in numerous cancers, but it remains unknown to what extent CTCFL deregulates transcription on its own or by opposing CTCF. Here, we discuss some of the potential mechanisms by which these two proteins could alter gene regulation and contribute to oncogenic transcriptional programs.

引用

页码：44 / 52

页数：9

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