RETRACTED: MicroRNA-363 inhibits ovarian cancer progression by inhibiting NOB1 (Retracted Article)

被引：23

作者：

Lin, Yang ^{[1
]}

Xu, Tianmin ^{[1
]}

Zhou, Shunqing ^{[1
]}

Cui, Manhua ^{[1
]}

机构：

[1] Jilin Univ, Hosp 2, Dept Obstet & Gynecol, Changchun 130041, Jilin, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 60期

关键词：

microRNAs; miR-363; ovarian cancer; NOB1; GASTRIC-CANCER; METASTASIS; EXPRESSION; MIR-363-3P; GROWTH; GENE; APOPTOSIS; INVASION; TARGETS; MCL-1;

D O I：

10.18632/oncotarget.21417

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study, we investigated the role of microRNA-363(miR-363) in ovarian cancer (OC) progression. MiR-363expression was downregulated in OC patient tissues and four OC cell lines (SKOV3, A2780, OVCAR and HO-8910). Low miR-363 levels were associated with advanced stage, lymph node metastasis, and poor prognosis in OC. MiR-363 overexpression decreased growth, colony formation, migration and invasiveness of SKOV3 cells. In addition, miR-363 overexpression in SKOV3 cells also decreased xenograft tumor size and weight in nude mice. Bioinformatics and dual luciferase reporter assays revealed that miR-363 suppresses expression of NIN1/RPN12 binding protein 1 homolog (NOB1) by binding to the 3'-UTR of its transcript. NOB1 expression inversely correlated with miR-363 levels in OC tissues. Thus miR-363 appears to play a tumor suppressor role in OC by inhibiting NOB1.

引用

页码：101649 / 101658

页数：10

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