Autologous stem cell transplantation in light-chain amyloidosis

被引：0

作者：

Boehm, Alexandra ^{[1
]}

机构：

[1] Hanusch Hosp, Med Dept 3, Heinrich Collin Str 30, A-1140 Vienna, Austria

来源：

MEMO-MAGAZINE OF EUROPEAN MEDICAL ONCOLOGY | 2021年 / 14卷 / 01期

关键词：

AL amyloidosis; High-dose melphalan; Autologous stem cell transplantation; Transplant-related mortality; HIGH-DOSE MELPHALAN; AL AMYLOIDOSIS; COMORBIDITY INDEX; BLOOD; SURVIVAL; DEXAMETHASONE;

D O I：

10.1007/s12254-020-00644-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Treatment of patients with light-chain amyloidosis (AL amyloidosis) has changed over the last 20 years, and early mortality rates have decreased with prolongation of survival. However, many patients are not cured with conventional therapy. Therefore, all patients should be assessed at diagnosis to determine eligibility for autologous stem cell transplantation (ASCT) since high-dose melphalan and ASCT have been shown to induce long-term hematologic and clinical responses with treatment-related mortality (TRM) <5%. Earlier diagnosis, improvement of supportive care, and deeper remissions with recently available first-line therapy have substantially reduced TRM. However, procedures and experience in complex AL amyloidosis patients still vary between transplant centers because a multidisciplinary team is necessary for an individual risk-adapted approach.

引用

页码：111 / 114

页数：4

共 25 条

[1] Outcomes with early vs. deferred stem cell transplantation in light chain amyloidosis [J].

Abdallah, Nadine ;

Sidana, Surbhi ;

Dispenzieri, Angela ;

Lacy, Martha ;

Buadi, Francis ;

Hayman, Suzanne ;

Kapoor, Prashant ;

Leung, Nelson ;

Dingli, David ;

Hwa, Yi Lisa ;

Lust, John ;

Russell, Stephen ;

Gonsalves, Wilson ;

Go, Ronald ;

Hogan, William ;

Kyle, Robert ;

Rajkumar, S. Vincent ;

Gertz, Morie ;

Kumar, Shaji .

BONE MARROW TRANSPLANTATION, 2020, 55 (07) :1297-1304

[2] Impact of consolidation therapy post autologous stem cell transplant in patients with light chain amyloidosis [J].

Al Saleh, Abdullah S. ;

Sidiqi, M. Hasib ;

Sidana, Surbhi ;

Muchtar, Eli ;

Dispenzieri, Angela ;

Dingli, David ;

Lacy, Martha Q. ;

Warsame, Rahma M. ;

Gonsalves, Wilson I. ;

Kourelis, Taxiarchis V. ;

Hogan, William J. ;

Hayman, Suzanne R. ;

Wolf, Robert C. ;

Kapoor, Prashant ;

Buadi, Francis K. ;

Kumar, Shaji K. ;

Gertz, Morie A. .

AMERICAN JOURNAL OF HEMATOLOGY, 2019, 94 (10) :1066-1071

[3] Hematopoietic Cell Transplantation-Specific Comorbidity Index Predicts Morbidity and Mortality in Autologous Stem Cell Transplantation [J].

Berro, Mariano ;

Arbelbide, Jorge A. ;

Rivas, Maria M. ;

Lisa Basquiera, Ana ;

Ferini, Gonzalo ;

Vitriu, Adriana ;

Foncuberta, Cecilia ;

Fernandez Escobar, Nicolas ;

Requejo, Alejandro ;

Milovic, Vera ;

Yantorno, Sebastian ;

Szelagoswki, Milagros ;

Martinez Rolon, Juliana ;

Bentolila, Gonzalo ;

Jose Garcia, Juan ;

Garcia, Pablo ;

Caeiro, Gaston ;

Castro, Martin ;

Jaimovich, Gregorio ;

Palmer, Silvina ;

Trucco, Jose I. ;

Bet, Lucia A. ;

Shaw, Bronwen E. ;

Kusminsky, Gustavo D. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2017, 23 (10) :1646-1650

[4] Risk-adapted autologous stem cell transplantation with adjuvant dexamethasone ± thalidomide for systemic light-chain amyloidosis:: results of a phase II trial [J].

Cohen, Adam D. ;

Zhou, Ping ;

Chou, Joanne ;

Teruya-Feldstein, Julie ;

Reich, Lilian ;

Hassoun, Hani ;

Levine, Beth ;

Filippa, Daniel A. ;

Riedel, Elyn ;

Kewalramani, Tarun ;

Stubblefield, Michael D. ;

Fleisher, Martin ;

Nimer, Stephen ;

Comenzo, Raymond L. .

BRITISH JOURNAL OF HAEMATOLOGY, 2007, 139 (02) :224-233

[5] Dose-intensive melphalan with blood stem cell support for the treatment of AL amyloidosis: One-year follow-up in five patients [J].

Comenzo, RL ;

Vosburgh, E ;

Simms, RW ;

Bergethon, P ;

Sarnacki, D ;

Finn, K ;

Dubrey, S ;

Faller, DV ;

Wright, DG ;

Falk, RH ;

Skinner, M .

BLOOD, 1996, 88 (07) :2801-2806

[6] Improved Outcomes After Autologous Hematopoietic Cell Transplantation for Light Chain Amyloidosis: A Center for International Blood and Marrow Transplant Research Study [J].

D'Souza, Anita ;

Dispenzieri, Angela ;

Wirk, Baldeep ;

Zhang, Mei-Jie ;

Huang, Jiaxing ;

Gertz, Morie A. ;

Kyle, Robert A. ;

Kumar, Shaji ;

Comenzo, Raymond L. ;

Gale, Robert Peter ;

Lazarus, Hillard M. ;

Savani, Bipin N. ;

Cornell, Robert F. ;

Weiss, Brendan M. ;

Vogl, Dan T. ;

Freytes, Cesar O. ;

Scott, Emma C. ;

Landau, Heather J. ;

Moreb, Jan S. ;

Costa, Luciano J. ;

Ramanathan, Muthalagu ;

Callander, Natalie S. ;

Kamble, Rammurti T. ;

Olsson, Richard F. ;

Ganguly, Siddhartha ;

Nishihori, Taiga ;

Kindwall-Keller, Tamila L. ;

Wood, William A. ;

Mark, Tomer M. ;

Hari, Parameswaran .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (32) :3741-+

[7] Superior survival in primary systemic amyloidosis patients undergoing peripheral blood stem cell transplantation: a case-control study [J].

Dispenzieri, A ;

Kyle, RA ;

Lacy, MQ ;

Therneau, TM ;

Larson, DR ;

Plevak, MF ;

Rajkumar, SV ;

Fonseca, R ;

Greipp, PR ;

Witzig, TE ;

Lust, JA ;

Zeldenrust, SR ;

Snow, DS ;

Hayman, SR ;

Litzow, MR ;

Gastineau, DA ;

Tefferi, A ;

Inwards, DJ ;

Micallef, IN ;

Ansell, SM ;

Porrata, LF ;

Elliott, MA ;

Gertz, MA .

BLOOD, 2004, 103 (10) :3960-3963

[8] Refinement in patient selection to reduce treatment-related mortality from autologous stem cell transplantation in amyloidosis [J].

Gertz, M. A. ;

Lacy, M. Q. ;

Dispenzieri, A. ;

Kumar, S. K. ;

Dingli, D. ;

Leung, N. ;

Hogan, W. J. ;

Buadi, F. K. ;

Hayman, S. R. .

BONE MARROW TRANSPLANTATION, 2013, 48 (04) :557-561

[9] Risk-adjusted manipulation of melphalan dose before stem cell transplantation in patients with amyloidosis is associated with a lower response rate [J].

Gertz, MA ;

Lacy, MQ ;

Dispenzieri, A ;

Ansell, SM ;

Elliott, MA ;

Gastineau, DA ;

Inwards, DJ ;

Micallef, INM ;

Porrata, LF ;

Tefferi, A ;

Litzow, MR .

BONE MARROW TRANSPLANTATION, 2004, 34 (12) :1025-1031

[10] Stem cell transplantation compared with melphalan plus dexamethasone in the treatment of immunoglobulin light-chain amyloidosis [J].

Gertz, Morie A. ;

Lacy, Martha Q. ;

Dispenzieri, Angela ;

Buadi, Francis K. ;

Dingli, David ;

Hayman, Suzanne R. ;

Kumar, Shaji K. ;

Leung, Nelson ;

Lust, John ;

Rajkumar, S. Vincent ;

Russell, Stephen J. ;

Suman, Vera J. ;

Le-Rademacher, Jennifer G. ;

Hogan, William J. .

CANCER, 2016, 122 (14) :2197-2205

← 1 2 3 →