Small RNAs in Germline Development

被引:31
作者
Cook, Matthew S. [1 ,2 ,3 ]
Blelloch, Robert [1 ,2 ,3 ]
机构
[1] Univ Calif San Francisco, Dept Urol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Ctr Reprod Sci, San Francisco, CA 94143 USA
来源
GAMETOGENESIS | 2013年 / 102卷
关键词
DOUBLE-STRANDED-RNA; SMALL INTERFERING RNAS; STEM-CELL MAINTENANCE; BINDING-PROTEIN; MESSENGER-RNA; SELF-RENEWAL; MICRORNA BIOGENESIS; ENDOGENOUS SIRNAS; GENE-EXPRESSION; DEAD-END;
D O I
10.1016/B978-0-12-416024-8.00006-4
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
One of the most important and evolutionarily conserved strategies to control gene expression in higher metazoa is posttranscriptional regulation via small regulatory RNAs such as microRNAs (miRNAs), endogenous small interfering RNAs (endo-siRNAs), and piwi-interacting RNAs (piRNAs). Primordial germ cells, which are defined by their totipotent potential and noted for their dependence on posttranscriptional regulation by RNA-binding proteins, rely on these small regulatory RNAs for virtually every aspect of their development, including specification, migration, and differentiation into competent gametes. Here, we review current knowledge of the roles miRNAs, endo-siRNAs, and piRNAs play at all stages of germline development in various organisms, focusing on studies in the mouse.
引用
收藏
页码:159 / 205
页数:47
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