Mechanisms and emerging functions of DNA degradation in the epidermis

被引：19
作者：
Eckhart, Leopold [1 ]
Fischer, Heinz [1 ]
Tschachler, Erwin [1 ,2 ]
机构：
[1] Med Univ Vienna, Dept Dermatol, Res Div Biol & Pathobiol Skin, A-1090 Vienna, Austria
[2] CE RIES, Neuilly Sur Seine, France
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2012年 / 17卷
基金：
奥地利科学基金会;
关键词：
Epidermis; Endonuclease; Exonuclease; Stratum Corneum; Apoptosis; Psoriasis; Antimicrobial Defense; Biofilm; Inflammation; Review; SINGLE NUCLEOTIDE POLYMORPHISMS; CASPASE-ACTIVATED DNASE; I-LIKE; STRATUM-CORNEUM; DEOXYRIBONUCLEASE-II; CELL-DEATH; SKIN CARCINOGENESIS; EXONUCLEASE TREX1; SALINE EXTRACTS; NUCLEAR-DNA;
D O I：
10.2741/4065
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Degradation of DNA is involved in key processes maintaining the integrity of the epidermis such as the cornification of keratinocytes, the removal of damaged cells and the defense against potentially harmful microorganisms. Recent studies have characterized some of the molecular mechanisms and physiological functions of DNA degradation in the epidermis. Deoxyribonuclease (DNase)1L2 and TREX2 were identified as epidermis-specific DNases and DNase 2 was shown to be the predominant DNA-degrading enzyme on the surface of the skin. Here we review the latest insights into the DNA catabolism in the skin and discuss open questions pertaining to the molecular biology of epidermal DNA breakdown.
引用
收藏
页码：2461 / 2475
页数：15
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