Mechanisms and emerging functions of DNA degradation in the epidermis

被引：19
作者：
Eckhart, Leopold [1 ]
Fischer, Heinz [1 ]
Tschachler, Erwin [1 ,2 ]
机构：
[1] Med Univ Vienna, Dept Dermatol, Res Div Biol & Pathobiol Skin, A-1090 Vienna, Austria
[2] CE RIES, Neuilly Sur Seine, France
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2012年 / 17卷
基金：
奥地利科学基金会;
关键词：
Epidermis; Endonuclease; Exonuclease; Stratum Corneum; Apoptosis; Psoriasis; Antimicrobial Defense; Biofilm; Inflammation; Review; SINGLE NUCLEOTIDE POLYMORPHISMS; CASPASE-ACTIVATED DNASE; I-LIKE; STRATUM-CORNEUM; DEOXYRIBONUCLEASE-II; CELL-DEATH; SKIN CARCINOGENESIS; EXONUCLEASE TREX1; SALINE EXTRACTS; NUCLEAR-DNA;
D O I：
10.2741/4065
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Degradation of DNA is involved in key processes maintaining the integrity of the epidermis such as the cornification of keratinocytes, the removal of damaged cells and the defense against potentially harmful microorganisms. Recent studies have characterized some of the molecular mechanisms and physiological functions of DNA degradation in the epidermis. Deoxyribonuclease (DNase)1L2 and TREX2 were identified as epidermis-specific DNases and DNase 2 was shown to be the predominant DNA-degrading enzyme on the surface of the skin. Here we review the latest insights into the DNA catabolism in the skin and discuss open questions pertaining to the molecular biology of epidermal DNA breakdown.
引用
收藏
页码：2461 / 2475
页数：15
相关论文
共 127 条
  • [1] Degradation by Stratum Corneum Proteases Prevents Endogenous RNase Inhibitor from Blocking Antimicrobial Activities of RNase 5 and RNase 7
    Abtin, Arby
    Eckhart, Leopold
    Mildner, Michael
    Ghannadan, Minoo
    Harder, Juergen
    Schroeder, Jens-Michael
    Tschachler, Erwin
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2009, 129 (09) : 2193 - 2201
  • [2] Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus
    Al-Mayouf, Sulaiman M.
    Sunker, Asma
    Abdwani, Reem
    Al Abrawi, Safiya
    Almurshedi, Fathiya
    Alhashmi, Nadia
    Al Sonbul, Abdullah
    Sewairi, Wafaa
    Qari, Aliya
    Abdallah, Eiman
    Al-Owain, Mohammed
    Al Motywee, Saleh
    Al-Rayes, Hanan
    Hashem, Mais
    Khalak, Hanif
    Al-Jebali, Latifa
    Alkuraya, Fowzan S.
    [J]. NATURE GENETICS, 2011, 43 (12) : 1186 - 1188
  • [3] Molecular cloning and characterization of human and murine DNase II
    Baker, KP
    Baron, WF
    Henzel, WJ
    Spencer, SA
    [J]. GENE, 1998, 215 (02) : 281 - 289
  • [4] Repair and genetic consequences of endogenous DNA base damage in mammalian cells
    Barnes, DE
    Lindahl, T
    [J]. ANNUAL REVIEW OF GENETICS, 2004, 38 : 445 - 476
  • [5] Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages
    Baron, WF
    Pan, CQ
    Spencer, SA
    Ryan, AM
    Lazarus, RA
    Baker, KP
    [J]. GENE, 1998, 215 (02) : 291 - 301
  • [6] Nuclease Expression by Staphylococcus aureus Facilitates Escape from Neutrophil Extracellular Traps
    Berends, Evelien T. M.
    Horswill, Alexander R.
    Haste, Nina M.
    Monestier, Marc
    Nizet, Victor
    von Koeckritz-Blickwede, Maren
    [J]. JOURNAL OF INNATE IMMUNITY, 2010, 2 (06) : 576 - 586
  • [7] Coordinated Host Responses during Pyroptosis: Caspase-1-Dependent Lysosome Exocytosis and Inflammatory Cytokine Maturation
    Bergsbaken, Tessa
    Fink, Susan L.
    den Hartigh, Andreas B.
    Loomis, Wendy P.
    Cookson, Brad T.
    [J]. JOURNAL OF IMMUNOLOGY, 2011, 187 (05) : 2748 - 2754
  • [8] Pyroptosis: host cell death and inflammation
    Bergsbaken, Tessa
    Fink, Susan L.
    Cookson, Brad T.
    [J]. NATURE REVIEWS MICROBIOLOGY, 2009, 7 (02) : 99 - 109
  • [9] DNase II and the Chk2 DNA damage pathway form a genetic barrier blocking replication of horizontally transferred DNA
    Bergsmedh, A
    Ehnfors, J
    Kawane, K
    Motoyama, N
    Nagata, S
    Holmgren, L
    [J]. MOLECULAR CANCER RESEARCH, 2006, 4 (03) : 187 - 195
  • [10] Apoptosis in the hair follicle
    Botchkareva, Natalia V.
    Ahluwalia, Gurpreet
    Shander, Douglas
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2006, 126 (02) : 258 - 264
12345678910