Paxiiones A-D, four new flavonoids from the stem of Mallotus paxii Pamp.

被引：3

作者：

Zhang, Yanjun ^{[1
,2
]}

Chen, Huangcan ^{[1
]}

Zhou, Dexiong ^{[1
]}

Liu, Wei ^{[1
]}

Zhang, Gaorong ^{[1
]}

Hao, Lili ^{[1
]}

Li, Chenguo ^{[1
]}

Yang, Ruiyun ^{[1
]}

Deng, Shengping ^{[1
]}

Li, Jun ^{[1
]}

Huang, Xishan ^{[1
]}

机构：

[1] Guangxi Normal Univ, Coll Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin, Peoples R China

[2] Beibu Gulf Univ, Sch Petr & Chem Engn, Qinzhou 535000, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2020年 / 37卷

基金：

中国国家自然科学基金;

关键词：

Mallows paxii Pamp; Flavonoids; Paxiione A; Paxiione B; Cytotoxic activity; BENZOPYRAN DERIVATIVES;

D O I：

10.1016/j.phytol.2020.03.011

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical investigation of the stems of Mallotus paxii Pamp., which are used for traditional Chinese medicinal treatment of viral infections in China, led to the isolation of four new flavonoids, paxiiones, A-D (1-4). Their structures were elucidated by spectroscopic analyses, including MS, NMR (1D and 2D), X-ray, experimental CD, and calculated ECD spectra. Compounds 1-4 were evaluated for their cytotoxic activities in KB, MCF7, and HepG-2 human cancer cell lines, and they exhibited cytotoxic activities, with IC50 values ranging from 8.62 mu M to 48.21 mu M. Compound 1 in particular showed significant cytotoxic activity in the KB cell line, with an IC50 value 8.62 mu M.

引用

页码：70 / 74

页数：5