Rotavirus immune responses and correlates of protection

被引：89

作者：

Angel, Juana ^{[1
]}

Franco, Manuel A. ^{[1
]}

Greenberg, Harry B. ^{[2
,3
]}

机构：

[1] Pontificia Univ Javeriana, Fac Med, Inst Genet Humana, Bogota, Colombia

[2] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN VIROLOGY | 2012年 / 2卷 / 04期

关键词：

ORAL POLIOVIRUS VACCINE; 1ST; 2; YEARS; SEVERE DIARRHEA; DOUBLE-BLIND; INFANTS; INFECTION; EFFICACY; GASTROENTERITIS; STRAINS; SAFETY;

D O I：

10.1016/j.coviro.2012.05.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Selected topics in the field of rotavirus immunity are reviewed focusing on recent developments that may improve efficacy and safety of current and future vaccines. Rotaviruses (RVs) have developed multiple mechanisms to evade interferon (IFN)-mediated innate immunity. Compared to more developed regions of the world, protection induced by natural infection and vaccination is reduced in developing countries where, among other factors, high viral challenge loads are common and where infants are infected at an early age. Studies in developing countries indicate that rotavirus-specific serum IgA levels are not an optimal correlate of protection following vaccination, and better correlates need to be identified. Protection against rotavirus following vaccination is substantially heterotypic; nonetheless, a role for homotypic immunity in selection of circulating postvaccination strains needs further study.

引用

页码：419 / 425

页数：7

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