Alkali Metal-Hydroxide-Catalyzed C(sp)-H Bond silylation

被引：85

作者：

Toutov, Anton A. ^{[1
]}

Betz, Kerry N. ^{[1
]}

Schuman, David P. ^{[1
]}

Liu, Wen-Bo ^{[1
]}

Fedorov, Alexey ^{[1
,2
]}

Stoltz, Brian M. ^{[1
]}

Grubbs, Robert H. ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

[2] Swiss Fed Inst Technol, Dept Chem & Appl Biosci, Vladimir Prelog Weg 2, CH-8093 Zurich, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2017年 / 139卷 / 04期

基金：

加拿大自然科学与工程研究理事会; 美国国家科学基金会;

关键词：

TERMINAL ALKYNES; GREEN CHEMISTRY; DEHYDROGENATIVE SILYLATION; ORGANOMETALLIC CHEMISTRY; AROMATIC HETEROCYCLES; CHEMICAL-SYNTHESIS; COUPLING REACTIONS; ORGANIC-SYNTHESIS; SILICON; HYDROSILANES;

D O I：

10.1021/jacs.6b12114

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Disclosed is a mild, scalable, and chemoselective catalytic cross-dehydrogenative C-H bond functionalization protocol for the construction of C(sp)-Si bonds in a single step. The scope of the alkyne and hydrosilane partners is substantial, providing an entry point into various organosilane building blocks and additionally enabling the discovery of a number of novel synthetic strategies. Remarkably, the optimal catalysts are NaOH and KOH.

引用

页码：1668 / 1674

页数：7

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