Pre-protective effect of polysaccharides purified from Hericium erinaceus against ethanol-induced gastric mucosal injury in rats

被引：41

作者：

Chen, Wanchao ^{[1
]}

Wu, Di ^{[1
]}

Jin, Yueling ^{[2
]}

Li, Qiaozhen ^{[1
]}

Liu, Yanfang ^{[1
]}

Qiao, Xuxin ^{[2
]}

Zhang, Jingsong ^{[1
]}

Dong, Guochao ^{[2
]}

Li, Zhengpeng ^{[1
]}

Li, Tingting ^{[2
]}

Yang, Yan ^{[1
]}

机构：

[1] Minist Agr, Shanghai Acad Agr Sci, Natl Engn Res Ctr Edible Fungi, Inst Edible Fungi,Key Lab Edible Fungi Resources, Shanghai 201403, Peoples R China

[2] Shanghai Univ Med & Hlth Sci, Shanghai 200237, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2020年 / 159卷

关键词：

Hericium erinaceus; Purified polysaccharide; Gastroprotective activity; Gastric ulcer; EPIDERMAL-GROWTH-FACTOR; INFLAMMATORY RESPONSES; BIOLOGICAL-ACTIVITIES; SIGNALING PATHWAYS; MUSHROOM; EXTRACTS; DAMAGE; STRESS; MICE; PROSTAGLANDIN;

D O I：

10.1016/j.ijbiomac.2020.05.163

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The beta-glucan H6PC20 (Mw: 2390 kDa) and alpha-heteropolysaccharide HPB-3 (Mw: 15 kDa) were purified from the fruiting body of Hericium erinaceus according to the previous methods. Their gastroprotective activities and cor-responding structure-activity relationship were studied in the ethanol-induced gastric ulcer model of rats. After intragastric administrated with H6PC20 and HPB-3 for 14 days, macroscopic and histological evaluation of gastric mucosa was improved significantly. The defense and repair factors (EGF, bFGF and PGE2) were increased, mean-while, the inflammatory cytokines (IL-1 beta and TNF-alpha) and MDA were reduced. These results indicated that H6PC20 and HPB-3 presented gastroprotective activities with the mechanism of activating repair and defense system, decreasing the inflammatory response and alleviating the oxidative injury. Furthermore, the structure -activity relationship showed that the macromolecular beta-glucan was better for repair and defense system, while the low weight molecular alpha-heteropolysaccharide focused on the anti-inflammatory effect. The polysac-charides purified from H. erinaceus can be developed as a potential gastroprotective ingredient for applications in pharmaceutical field. (C) 2020 Published by Elsevier B.V.

引用

页码：948 / 956

页数：9

共 43 条

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