Anti-diabetic effect of S-adenosylmethionine and α-glycerophosphocholine in KK-Ay mice

被引：6

作者：

Izu, Hanae ^{[1
]}

Okuda, Mayumi ^{[2
]}

Shibata, Sachi ^{[3
]}

Fujii, Tsutomu ^{[1
,4
]}

Matsubara, Kiminori ^{[2
]}

机构：

[1] Natl Res Inst Brewing, Safety & Qual Div, Higashihiroshima, Japan

[2] Hiroshima Univ, Grad Sch Educ, Dept Human Life Sci Educ, Higashihiroshima, Japan

[3] Fukuyama Univ, Fac Life Sci & Biotechnol, Dept Nutr & Life Sci, Fukuyama, Hiroshima, Japan

[4] Hiroshima Univ, Grad Sch Biosphere Sci, Sch Appl Biol Sci, Higashihiroshima, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2019年 / 83卷 / 04期

关键词：

S-adenosylmethionine; alpha-glycerophosphocholine; leptin; KK-A(y) mouse; INSULIN-RESISTANCE; METHIONINE; LIVER;

D O I：

10.1080/09168451.2018.1559721

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six-week-old male KK-A(y) mice received drinking water with S-adenosylmethionine (SAM), alpha-glycerophosphocholine (GPC), or SAM+GPC for 10 weeks. The serum glucose of SAM+GPC at 15 weeks old, total cholesterol of GPC at 12 weeks old, and triglyceride of GPC at 15 weeks old and of SAM at 16 weeks old were reduced. SAM+GPC reduced serum leptin and food intake.

引用

页码：747 / 750

页数：4

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