Prolonged and symptomatic bradycardia following a single dose of fingolimod

被引：23

作者：

Faber, Hans ^{[1
]}

Fischer, Hans-Joerg ^{[2
]}

Weber, Frank ^{[1
]}

机构：

[1] Max Planck Inst Psychiat, D-80804 Munich, Germany

[2] Klinikum Schwabing, Munich Municipal Hosp Grp, Dept Emergency Med, Munich, Germany

来源：

MULTIPLE SCLEROSIS JOURNAL | 2013年 / 19卷 / 01期

关键词：

bradycardia; disease modifying therapies; fingolimod; multiple sclerosis; RELAPSING MULTIPLE-SCLEROSIS; HEALTHY-SUBJECTS; ORAL FINGOLIMOD; FTY720; TRIAL;

D O I：

10.1177/1352458512447596

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Fingolimod-related bradycardia is usually asymptomatic, reaches its nadir within 6 hours post-dose and recovers spontaneously. Here we report the case of a 30-year-old MS patient with vagotonia who developed symptomatic bradycardia with 33 beats per minute at nadir 39 hours after a single dose of fingolimod. Bradycardia was responsive to atropine, but returned within 2 hours. Overall, it took a week until the patient recovered. Extended monitoring is advised in patients with symptomatic bradycardia.

引用

收藏

页码：126 / 128

页数：3

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