Coping with Loss: Cell Adaptation to Cytoskeleton Disruption

被引：3

作者：

McGarry, David J. ^{[1
]}

Olson, Michael F. ^{[1
,2
]}

机构：

[1] Canc Res UK Beatson Inst, Garscube Estate,Switchback Rd, Glasgow G61 1BD, Lanark, Scotland

[2] Univ Glasgow, Inst Canc Sci, Glasgow G12 8QQ, Lanark, Scotland

来源：

DEVELOPMENTAL CELL | 2016年 / 39卷 / 01期

基金：

英国医学研究理事会;

关键词：

MUTATIONS; ISG15;

D O I：

10.1016/j.devcel.2016.09.020

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Unravelling the role of cytoskeleton regulators may be complicated by adaptations to experimental manipulations. In this issue of Developmental Cell, Cerikan et al. (2016) reveal how acute effects of DOCK6 RhoGEF depletion on RAC1 and CDC42 activation are reversed over time by compensatory mechanisms that reestablish cellular homeostasis.

引用

页码：3 / 4

页数：2

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