DNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma

被引：17

作者：

Ozdemir, Nihal ^{[1
]}

Celkan, Tiraje

Baris, Safa ^{[2
]}

Batar, Bahadir ^{[3
]}

Guven, Mehmet ^{[3
]}

机构：

[1] IU Cerrahpasa Tip Fak, Cerrahpasa Med Fac, Dept Pediat Hematol Oncol, Cocuk Hemat BD, Istanbul, Turkey

[2] Marmara Univ, Dept Pediat Allergy Immunol, Istanbul, Turkey

[3] Cerrahpasa Med Fac, Dept Med Biol, Istanbul, Turkey

来源：

LEUKEMIA RESEARCH | 2012年 / 36卷 / 05期

关键词：

Febrile neutropenia; XRCC1 and XPD polymorphisms; Mucositis; CANCER; ASSOCIATION; IMMUNODEFICIENCY; SUSCEPTIBILITY; CHEMOTHERAPY; RADIOTHERAPY; MORTALITY; TOXICITY; CAPACITY; ERCC2;

D O I：

10.1016/j.leukres.2011.10.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of the study is to investigate association between DNA repair gene XPD and XRCC1 polymorphisms and febrile neutropenia (FN) and mucositis. The study population consisted of 29 children with Burkitt lymphoma and 61 children with acute lymphoblastic leukemia. Analysis revealed that XRCC1194Trp allele showed a protective effect against longer FN and mucositis. There was also statistically increased risk for severe mucositis in patients with XRCC1Arg399Gln polymorphism. There are no studies that have examined this relationship before. Further studies with larger cohorts are needed to clarify the association. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：565 / 569

页数：5

共 35 条

[1]

Baorto EP, 2001, CANCER, V92, P909, DOI 10.1002/1097-0142(20010815)92:4<909::AID-CNCR1400>3.0.CO

[2]

2-H

[3]

Baris S, 2009, PEDIATR HEMAT ONCOL, V26, P467, DOI [10.1080/08880010903096201, 10.3109/08880010903096201]

[4] DNA repair gene XPD and XRCC1 polymorphisms and the risk of childhood acute lymphoblastic leukemia [J].