The Establishment and cultivation of innovation ecosystem not only helps to enhance the competitiveness of the countries and regions, but also is the national and regional powerful thrusting and strategic objectives. Colleges in the regional innovation system as the core of ecological organization, it is also the source of original creation knowledge and technology, and provides mechanisms for diversification of the knowledge transfer. How to make the innovation ecosystem dominated in the perspective of regional development synergies and sustainable development has become an important issue. Based on this background, a synergetic evolution model of innovation ecosystem dominated by colleges and universities, named Lokata-Volterra, is put forward from ecological perspective. Through the mathematical analysis, the cooperative evolution law of all kinds of species in the innovative ecosystem is discussed. This paper takes Chongqing University National University Science Park and Beibei National University Science Park as the research object, and fuse Logistic mode to analyze the dynamic evolution process of innovation ecosystem. The results show that the innovation ecosystem, which is dominated by the University, needs to link the internal and external resources and the platform to realize the diversity of the main body of the ecosystem.
