Neuropsychiatric manifestations in rheumatoid arthritis

被引：60

作者：

Joaquim, Andrei F. ^{[1
]}

Appenzeller, Simone ^{[2
]}

机构：

[1] State Univ Campinas UNICAMP, Dept Neurol, BR-13083970 Campinas, SP, Brazil

[2] State Univ Campinas UNICAMP, Dept Med, BR-13083970 Campinas, SP, Brazil

来源：

AUTOIMMUNITY REVIEWS | 2015年 / 14卷 / 12期

关键词：

Rheumatoid arthritis; Neurological manifestations; Peripheral neuropathy; Cervical spine; Brain; NEUROLOGICAL ADVERSE EVENTS; CERVICAL-SPINE INVOLVEMENT; TARSAL TUNNEL-SYNDROME; PERIPHERAL NEUROPATHY; COGNITIVE IMPAIRMENT; ALPHA THERAPY; FOLLOW-UP; DEPRESSION; VASCULITIS; PATIENT;

D O I：

10.1016/j.autrev.2015.07.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rheumatoid arthritis (RA) is a chronic disease characterized by persistent synovitis, systemic inflammation, and the presence of autoantibodies. Neuropsychiatric manifestations are quite common in RA, including depression, cognitive dysfunction, behavior changes, spinal cord compression and peripheral nerve involvement. Potential causes include systemic inflammatory process, neural compression due to bone and joint destruction, side effects of medications and copying difficulties due to the chronicity of the disease. A high level of suspicious is required for an adequate diagnosis and treatment. In this review, we will discuss topographically the main neuropsychiatric manifestations described in RA patients, in an attempt to help in the management of these complex and multifaceted disease. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：1116 / 1122

页数：7

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