Neuroimaging Findings Related to Behavioral Disturbances in Alzheimer's Disease: A Systematic Review

被引:34
作者
Alves, Gilberto Sousa [1 ,2 ,3 ]
Carvalho, Andre Ferrer [2 ,3 ]
de Carvalho, Luiza de Amorim [2 ,3 ]
Sudo, Felipe Kenji [4 ]
Siqueira-Neto, Jose Ibiapina [2 ,3 ]
Oertel-Knoechel, Viola [5 ]
Jurcoane, Alina [6 ]
Knoechel, Christian [5 ]
Boecker, Henning [6 ]
Laks, Jerson [4 ,7 ,8 ]
Pantel, Johannes [1 ]
机构
[1] Goethe Univ, Inst Gen Med, Frankfurt, Germany
[2] Univ Fed Ceara, Translat Psychiat Res Grp, Fortaleza, Ceara, Brazil
[3] Univ Fed Ceara, Dept Clin Med, Fortaleza, Ceara, Brazil
[4] Univ Fed Rio de Janeiro, Inst Psychiat, Rio De Janeiro, Brazil
[5] Goethe Univ, Dept Psychiat Psychosomat Med & Psychotherapy, Lab Neurosci, Frankfurt, Germany
[6] Univ Bonn, Dept Radiol, Clin Funct Neuroimaging Grp, Bonn, Germany
[7] Inst Vital Brazil, Ctr Studies & Res Aging, Rio De Janeiro, Brazil
[8] Unigranrio, Translat Biomed Program, Rio De Janeiro, Brazil
关键词
Alzheimer's disease; behavior; BPSD; cognition; cortical; neuroimaging; psychological; symptoms; white matter; TRANSCRANIAL MAGNETIC STIMULATION; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHIATRIC-SYMPTOMS; DEPRESSIVE SYMPTOMS; PSYCHOLOGICAL SYMPTOMS; TEMPORAL-LOBE; APATHY; ATROPHY; BRAIN; DEMENTIA;
D O I
10.2174/1567205013666160603010203
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Behavioral and psychological symptoms of dementia (BPSD) associated with Alzheimer ' s Disease (AD) have been linked to structural and functional alterations in fronto-temporal circuits and cortical abnormalities. However, little is known on how specific volumetric and functional brain changes may be associated with the frequency, severity and pattern of BPSD. Methods: A systematic review of the literature regarding neuroimaging and BPSD changes in AD was performed through Pubmed/Medline, ISI, and EMBASE electronic databases from January 2000 to May 2015. Eligible references (n=40) included clinical studies in which structural or functional neuroimaging assessment was performed in AD subjects presenting BPSD features. Results: BPSD symptoms, particularly apathy and psychosis have been associated in most of studies with either volume reductions or decreased metabolism in the prefrontal cortex (orbital and dorsolateral portions), anterior cingulate, insula and temporal lobes (middle portion). WM lacunes associated with AD progression have been associated with depressive symptoms. Conclusion: The sum of evidence highlights the importance of BPSD-related imaging findings for the understanding of the non-cognitive symptom spectrum in AD. Results suggest that structural and functional changes in fronto-limbic areas may lead to emotional deregulation and symptom unawareness. As these findings may be present early on the AD clinical course, they may have a relevance for the development of imaging markers that could be used in diagnosis, disease monitoring and prediction of therapeutic response.
引用
收藏
页码:61 / 75
页数:15
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