Modeling, design and synthesis of new heteroaryl ethylenes active against the MCF-7 breast cancer cell-line

被引：28

作者：

Barresi, Vincenza ^{[1
]}

Bonaccorso, Carmela ^{[2
]}

Consiglio, Giuseppe ^{[3
]}

Goracci, Laura ^{[2
]}

Musso, Nicolo ^{[1
]}

Musumarra, Giuseppe ^{[2
]}

Satriano, Cristina ^{[2
]}

Fortuna, Cosimo G. ^{[2
]}

机构：

[1] Univ Catania, Dipartimento Sci Biomed, Sez Biochim, I-95125 Catania, Italy

[2] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy

[3] Univ Catania, Dipartimento Ingn Ind & Meccan, I-95125 Catania, Italy

来源：

MOLECULAR BIOSYSTEMS | 2013年 / 9卷 / 10期

关键词：

VITRO ANTITUMOR-ACTIVITY; IN-SILICO DISCOVERY; QSAR MODEL; CHEMOTHERAPY; AGENTS; TRANS; DRUG; ANTAGONISTS; BIOMARKERS; CHEMISTRY;

D O I：

10.1039/c3mb70151d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A dataset of 50 compounds was used to generate a QSAR model and to design 9 new heteroaryl ethylenes. These compounds were synthesized, tested in vitro and a significant agreement with in silico predictions observed. Studies using Laser Scanning Confocal Microscopy pointed out that the compounds may act by different mechanisms.

引用

页码：2426 / 2429

页数：4

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