Brain tumour stem cells

被引：751
作者：
Vescovi, Angelo L. [1 ]
Galli, Rossella
Reynolds, Brent A.
机构：
[1] Univ Milano Bicocca, Dept Biosci & Biotechnol, I-20126 Milan, Italy
[2] Ist Sci San Raffaele, DIBIT, Stem Cell Res Inst, I-20132 Milan, Italy
[3] Univ Queensland, Brisbane, Qld 4072, Australia
来源：
NATURE REVIEWS CANCER | 2006年 / 6卷 / 06期
关键词：
D O I：
10.1038/nrc1889
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The dogma that the genesis of new cells is a negligible event in the adult mammalian brain has long influenced our perception and understanding of the origin and development of CNS tumours. The discovery that new neurons and glia are produced throughout life from neural stem cells provides new possibilities for the candidate cells of origin of CNS neoplasias. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies.
引用
收藏
页码：425 / 436
页数：12
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