Dopamine autoreceptor reserve in vitro: Possible role of dopamine D-3 receptors

被引：7

作者：

Aretha, CW ^{[1
]}

Galloway, MP ^{[1
]}

机构：

[1] WAYNE STATE UNIV,SCH MED,DEPT PSYCHIAT & BEHAV NEUROSCI,CELLULAR & CLIN NEUROBIOL PROGRAM,DETROIT,MI 48202

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 305卷 / 1-3期

关键词：

receptor reserve; dopamine D; receptor; 7-OH-DPAT; (7-hydroxy-N; N-di-n-propyl-2-aminotetralin);

D O I：

10.1016/0014-2999(96)00142-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Receptor alkylation in vivo with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) decreased the potency, but not the efficacy, of the dopamine D-3 receptor-preferring agonist 7-hydroxy-N, N-di-n-propyl-2-aminotetralin (7-OH DPAT) at synthesis modulating dopamine autoreceptors in striatal and olfactory tubercle slices stimulated by 30 mM K+. In contrast, 7-OH-DPAT was ineffective in slices exposed to forskolin (10 mu M). The results support the presence of autoreceptor reserve in vitro, and the partial involvement of dopamine D, receptors in the autoregulation of dopamine synthesis.

引用

页码：119 / 122

页数：4

共 18 条

[1]

ARETHA CW, 1995, J PHARMACOL EXP THER, V274, P609

[2]

BOHMAKER K, 1989, J PHARMACOL EXP THER, V248, P97

[3] LACK OF DISCRIMINATION BY AGONISTS FOR D-2 AND D-3 DOPAMINE-RECEPTORS [J].