Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

被引:184
作者
Choi, Bu Young [1 ]
机构
[1] Seowon Univ, Dept Pharmaceut Sci & Engn, Cheongju 28674, Chungbuk, South Korea
关键词
hair loss; Wnt/beta-catenin signaling; DERMAL PAPILLA CELLS; PROMOTES PROLIFERATION; ALOPECIA-AREATA; GROWTH; FOLLICLE; EXPRESSION; ACTIVATION; DICKKOPF-1; INDUCTION; MORPHOGENESIS;
D O I
10.3390/ijms21144915
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Persistent hair loss is a major cause of psychological distress and compromised quality of life in millions of people worldwide. Remarkable progress has been made in understanding the molecular basis of hair loss and identifying valid intracellular targets for designing effective therapies for hair loss treatment. Whereas a variety of growth factors and signaling pathways have been implicated in hair cycling process, the activation of Wnt/beta-catenin signaling plays a central role in hair follicle regeneration. Several plant-derived chemicals have been reported to promote hair growth by activating Wnt/beta-catenin signaling in various in vitro and in vivo studies. This mini-review sheds light on the role of Wnt/beta-catenin in promoting hair growth and the current progress in designing hair loss therapies by targeting this signaling pathway.
引用
收藏
页码:1 / 16
页数:16
相关论文
共 82 条
[1]   The Prevalence of Infections With Trichophyton tonsurans in Schoolchildren: the CAPITIS Study [J].
Abdel-Rahman, Susan M. ;
Farrand, Nancy ;
Schuenemann, Eric ;
Stering, Tricia K. ;
Preuett, Barry ;
Magie, Richard ;
Campbell, Annette .
PEDIATRICS, 2010, 125 (05) :966-973
[2]   In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn [J].
Adhirajan, N ;
Kumar, TR ;
Shanmugasundaram, N ;
Babu, M .
JOURNAL OF ETHNOPHARMACOLOGY, 2003, 88 (2-3) :235-239
[3]   Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling [J].
Ahmed, Noha S. ;
Ghatak, Subhadip ;
El Masry, Mohamed S. ;
Gnyawali, Surya C. ;
Roy, Sashwati ;
Amer, Mohamed ;
Everts, Helen ;
Sen, Chandan K. ;
Khanna, Savita .
MOLECULAR THERAPY, 2017, 25 (11) :2502-2512
[4]   WNT signals are required for the initiation of hair follicle development [J].
Andl, T ;
Reddy, ST ;
Gaddapara, T ;
Millar, SE .
DEVELOPMENTAL CELL, 2002, 2 (05) :643-653
[5]   Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow [J].
Bafico, A ;
Liu, GZ ;
Yaniv, A ;
Gazit, A ;
Aaronson, SA .
NATURE CELL BIOLOGY, 2001, 3 (07) :683-686
[6]   β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoyiquinic acid [J].
Bejaoui, Meriem ;
Villareal, Myra O. ;
Isoda, Hiroko .
AGING-US, 2019, 11 (12) :4216-4237
[7]   Wnt signaling: An embarrassment of receptors [J].
Bejsovec, A .
CURRENT BIOLOGY, 2000, 10 (24) :R919-R922
[8]  
Beoy LA, 2010, TROP LIFE SCI RES, V21, P91
[9]   Epidermal homeostasis: a balancing act of stem cells in the skin [J].
Blanpain, Cedric ;
Fuchs, Elaine .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (03) :207-U67
[10]   Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation [J].
Chen, Demeng ;
Jarrell, Andrew ;
Guo, Canting ;
Lang, Richard ;
Atit, Radhika .
DEVELOPMENT, 2012, 139 (08) :1522-1533