US EPA particulate matter research centers: summary of research results for 2005-2011

被引：42

作者：

Breysse, Patrick N. ^{[1
]}

Delfino, Ralph J. ^{[2
]}

Dominici, Francesca ^{[5
]}

Elder, Alison C. P. ^{[3
]}

Frampton, Mark W. ^{[3
]}

Froines, John R. ^{[4
]}

Geyh, Alison S. ^{[1
]}

Godleski, John J. ^{[5
]}

Gold, Diane R. ^{[5
]}

Hopke, Philip K. ^{[6
]}

Koutrakis, Petros ^{[5
]}

Li, Ning ^{[4
]}

Oberdoerster, Guenter ^{[3
]}

Pinkerton, Kent E. ^{[7
]}

Samet, Jonathan M. ^{[8
]}

Utell, Mark J. ^{[3
]}

Wexler, Anthony S. ^{[7
,9
]}

机构：

[1] Johns Hopkins Univ, Baltimore, MD USA

[2] Univ Calif Irvine, Irvine, CA USA

[3] Univ Rochester, Rochester, NY USA

[4] Univ Calif Los Angeles, Los Angeles, CA USA

[5] Harvard Univ, Cambridge, MA 02138 USA

[6] Clarkson Univ, Potsdam, NY USA

[7] Univ Calif Davis, Davis, CA 95616 USA

[8] Univ So Calif, Los Angeles, CA USA

[9] Univ Calif Davis, Air Qual Res Ctr, Davis, CA 95616 USA

来源：

AIR QUALITY ATMOSPHERE AND HEALTH | 2013年 / 6卷 / 02期

关键词：

Airpollution; Particulate matter; Exposure; Susceptibility; Source-health relationships; Acute effects; Chronic effects; Biological mechanisms; Epidemiological associations; HEART-RATE-VARIABILITY; AMBIENT AIR-POLLUTION; AEROSOLS (TERESA)-POWER PLANT; CARBON ULTRAFINE PARTICLES; SECONDARY ORGANIC AEROSOL; CARDIAC OXIDATIVE STRESS; CASE-CROSSOVER ANALYSIS; ST-SEGMENT DEPRESSION; SHORT-TERM EXPOSURE; LOS-ANGELES;

D O I：

10.1007/s11869-012-0181-8

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The US Environmental Protection Agency funded five academic research centers in 2005 to address uncertainties in the health effects caused by airborne particulate matter (PM) as suggested by the 1998 National Research Council report, "Research Priorities for Airborne Particulate Matter." The centers employed multidisciplinary teams of epidemiologists, toxicologists, atmospheric scientists, engineers, and chemists to approach four key research themes: susceptibility to PM, biological mechanisms of PM response, exposure-response relationships, and source linkages. This review presents selected accomplishments in these categories from the past 5-year period. Publications from the centers are summarized to provide both an overview of the accomplishments to date and easy reference to much of the original literature published by the centers. Numerous investigators worked together within and across centers to investigate the relationships between atmospheric PM and health effects, including (a) the role of reactive oxygen species, inflammation, the nervous system, and the cardiovascular system, (b) particle characteristics such as size, composition, source, and temporal pattern of exposure, and (c) phenotypic and genotypic characteristics of the population that influence the level of exposure and risk in response to a given exposure.

引用

页码：333 / 355

页数：23

共 169 条

[1] Association between air pollution exposure and exhaled nitric oxide in an elderly population [J].