Effects of polysaccharides from bee collected pollen of Chinese wolfberry on immune response and gut microbiota composition in cyclophosphamide-treated mice

被引：69

作者：

Zhao, Ya ^{[1
]}

Yan, Yamei ^{[2
]}

Zhou, Wangting ^{[1
]}

Chen, Dan ^{[1
]}

Huang, Kaiyin ^{[1
]}

Yu, Shijie ^{[1
]}

Mi, Jia ^{[2
]}

Lu, Lu ^{[2
]}

Zeng, Xiaoxiong ^{[1
]}

Cao, Youlong ^{[2
]}

机构：

[1] Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Peoples R China

[2] Natl Wolfberry Engn Res Ctr, Yinchuan 750002, Ningxia, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2020年 / 72卷

关键词：

Bee collected pollen; Chinese wolfberry; Polysaccharide; Gut microbiota; Immunoregulation; HEALTH; SYSTEM;

D O I：

10.1016/j.jff.2020.104057

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The gut microbiota has emerged as an important contributor to the immune system and it is believed to be regulated by dietary fiber. In this study, therefore, the immunomodulatory and gut microbiota modulatory effects of polysaccharides from bee collected pollen of Chinese wolfberry (WBPPS) in cyclophosphamide (CTX)-treated mice were investigated. The results showed that WBPPS could enhance thymus and spleen indices and promote production of immune-related cytokines (IgA, TNF-alpha, TGF-beta 1 and IL-10) in serum of CTX-treated mice. In addition, WBPPS could significantly improve hepatic function and oxidative stress in CTX-treated mice via increasing the levels of GSH, SOD and CAT and decreasing the levels of ALT and MDA. More importantly, WBPPS remarkably increased the relative abundances of Family_XIII, Ruminococcaceae and Saccharimonadaceae while decreased the relative abundances of Tannerellaceae, Marinifilaceae and Rikenellaceae, which were closely associated with immune traits. Overall, WBPPS might be developed as a promising immunomodulator in functional foods.

引用

页数：11

共 43 条

[1] The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy
Ahlmann, Martina
Hempel, Georg
[J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2016, 78 (04) : 661 - 671
[2] Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation
Bao, Qi
Li, Chong
Xu, Chongfeng
Zhang, Ruiying
Zhao, Kai
Duan, Ziyuan
[J]. GENE, 2018, 646 : 47 - 55
[3] Role of the Microbiota in Immunity and Inflammation
Belkaid, Yasmine
Hand, Timothy W.
[J]. CELL, 2014, 157 (01) : 121 - 141
[4] Structural and immunological properties of arabinogalactan polysaccharides from pollen of timothy grass (Phleum pratense L.)
Brecker, L
Wicklein, D
Moll, H
Fuchs, EC
Becker, WM
Petersen, A
[J]. CARBOHYDRATE RESEARCH, 2005, 340 (04) : 657 - 663
[5] Toll-Like Receptor-Gut Microbiota Interactions: Perturb at Your Own Risk!
Carvalho, Frederic A.
Aitken, Jesse D.
Vijay-Kumar, Matam
Gewirtz, Andrew T.
[J]. ANNUAL REVIEW OF PHYSIOLOGY, VOL 74, 2012, 74 : 177 - 198
[6] Polysaccharide from natural Cordyceps sinensis ameliorated intestinal injury and enhanced antioxidant activity in immunosuppressed mice
Chen, Shuping
Wang, Junqiao
Fang, Qiuyue
Dong, Nan
Nie, Shaoping
[J]. FOOD HYDROCOLLOIDS, 2019, 89 : 661 - 667
[7] The Impact of the Gut Microbiota on Human Health: An Integrative View
Clemente, Jose C.
Ursell, Luke K.
Parfrey, Laura Wegener
Knight, Rob
[J]. CELL, 2012, 148 (06) : 1258 - 1270
[8] Exploring the impact of Helicobacter pylori on gut microbiome composition
Dash, Nihar Ranjan
Khoder, Ghalia
Nada, Aml Mohamed
Al Bataineh, Mohammad Tahseen
[J]. PLOS ONE, 2019, 14 (06):
[9] Ding Y, 2019, FOOD FUNCT, V10, P3671, DOI [10.1039/c9fo00638a, 10.1039/C9FO00638A]
[10] Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides
Frantz, A. L.
Rogier, E. W.
Weber, C. R.
Shen, L.
Cohen, D. A.
Fenton, L. A.
Bruno, M. E. C.
Kaetzel, C. S.
[J]. MUCOSAL IMMUNOLOGY, 2012, 5 (05) : 501 - 512

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