EG-VEGF: a key endocrine factor in placental development

被引：62
作者：
Brouillet, Sophie [1 ,2 ,3 ]
Hoffmann, Pascale [1 ,2 ,3 ,4 ]
Feige, Jean-Jacques [1 ,2 ,3 ]
Alfaidy, Nadia [1 ,2 ,3 ]
机构：
[1] INSERM, Unite 1036, Grenoble, France
[2] Commissariat Energie Atom, Inst Rech Technol & Sci Vivant iRTSV Biol Canc &, Grenoble, France
[3] Univ Grenoble 1, F-38041 Grenoble, France
[4] Ctr Hosp Univ Grenoble, Dept Gynecol Obstet & Med Reprod, Grenoble, France
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2012年 / 23卷 / 10期
关键词：
ENDOTHELIAL GROWTH-FACTOR; HUMAN CHORIONIC-GONADOTROPIN; CIRCULATING ANGIOGENIC FACTORS; 1ST TRIMESTER; PROKINETICIN RECEPTOR-1; MOLECULAR CHARACTERIZATION; OXYGEN REGULATION; FACTOR-BETA; EXPRESSION; IDENTIFICATION;
D O I：
10.1016/j.tem.2012.05.006
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Endocrine gland-derived vascular endothelial growth factor (EG-VEGF), also named prokineticin 1, is the canonical member of the prokineticin family. Numerous reports suggest a direct involvement of this peptide in normal and pathological reproductive processes. Recent advances propose EG-VEGF as a key endocrine factor that controls many aspects of placental development and suggest its involvement in the development of pre-eclampsia (PE), the most threatening pathology of human pregnancy. This review describes the finely tuned action and regulation of EG-VEGF throughout human pregnancy, argues for its clinical relevance as a potential diagnostic marker of the onset of PE, and discusses future research directions for therapeutic targeting of EG-VEGF.
引用
收藏
页码：501 / 508
页数：8
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