A new sesquiterpenoid from Polyalthia petelotii

被引：8

作者：

Yang, Caiqiong ^{[1
]}

Peng, Wei ^{[1
]}

Yang, Bijuan ^{[1
]}

Zhang, Junjie ^{[1
]}

Chen, Yegao ^{[1
]}

机构：

[1] Yunnan Normal Univ, Sch Chem & Chem Engn, Kunming, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 14期

关键词：

Polyalthia petelotii; Annonaceae; sesquiterpenoid; CHEMICAL-CONSTITUENTS; CLERODANE DITERPENES; LONGIFOLIA; LEAVES; ANTIOXIDANT; ROOTS;

D O I：

10.1080/14786419.2015.1118633

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new sesquiterpenoid (-)-ethyl dihydrophaseate (1) was isolated from the stems and leaves of Polyalthia petelotii, together with two clerodane diterpenoids, 16 alpha-hydroxycleroda-3,13(14)Z-dien-15,16-olide (2), 15-hydroxy-cis-ent-cleroda-3,13(E)-diene (3), a eudesmane sesquiterpenoid, eudesm-4(15)-ene-7 alpha,11-diol (4), an aromatic aldehyde, vanillin (5), a bisisoquinolines alkaloid, spinosine (6) and an aporphine alkaloid, (-)-oliveroline-beta-N-oxide (7). Their structures were established by extensive spectroscopic analysis, including 2D-NMR techniques. Compounds 3, 4 and 6 were isolated from the genus Polyalthia for the first time and the others obtained originally from P. petelotii. The isolates were assessed for their cytotoxicity against five human tumour lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and the result showed that only 2 displayed weak inhibitory activity. [GRAPHICS] .

引用

页码：1565 / 1570

页数：6

共 25 条

[1] Antiplasmodial constituents from the stem bark of Polyalthia longifolia var pendula [J].

Annan, Kofi ;

Ekuadzi, Edmund ;

Asare, Cindy ;

Sarpong, Kwame ;

Pistorius, Dominik ;

Oberer, Lukas ;

Gyan, Ben A. ;

Ofori, Michael .

PHYTOCHEMISTRY LETTERS, 2015, 11 :28-31

[2] Clerodane type diterpene as a novel antifungal agent from Polyalthia longifolia var. pendula [J].

Bhattacharya, Asish K. ;

Chand, Hemender R. ;

John, Jyothis ;

Deshpande, Mukund V. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 94 :1-7

[3] ent-Clerodane diterpenes and other constituents from the liverwort Adelanthus lindenbergianus (Lehm.) Mitt. [J].

Bläs, B ;

Zapp, J ;

Becker, H .

PHYTOCHEMISTRY, 2004, 65 (01) :127-137

[4] Cytotoxic constituents of Polyalthia longifolia var. pendula [J].

Chen, CY ;

Chang, FR ;

Shih, YC ;

Hsieh, TJ ;

Chia, YC ;

Tseng, HY ;

Chen, HC ;

Chen, SJ ;

Hsu, MC ;

Wu, YC .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (11) :1475-1478

[5] Antioxidant and antityrosinase proanthocyanidins from Polyalthia longifolia leaves [J].

Chen, Xiao-Xin ;

Liang, Ge ;

Chai, Wei-Ming ;

Feng, Hui-Ling ;

Zhou, Han-Tao ;

Shi, Yan ;

Chen, Qing-Xi .

JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2014, 118 (05) :583-587

[6]

CUI BL, 1993, CHEM PHARM BULL, V41, P178, DOI 10.1248/cpb.41.178

[7] Chemical composition of essential oils from the leaves and stem barks of Vietnamese species of Polyalthia harmandiiPolyalthia jucunda and Polyalthia thorelii [J].

Dai, Do N. ;

Thang, Tran D. ;

Ogunwande, Isiaka A. .

NATURAL PRODUCT RESEARCH, 2014, 28 (08) :555-562

[8]

Jiang Y, 1979, FLORA REIPUBLICAE PO, V30, P83

[9] Bioactive constituents of the roots of Polyalthia cerasoides [J].

Kanokmedhakul, Somdej ;

Kanokmedhakul, Kwanjai ;

Lekphrom, Ratsami .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (09) :1536-1538

[10] Constituents of Polyalthia longifolia var. pendula [J].

Lee, Tzong-Huei ;

Wang, Mei-Jhen ;

Chen, Pi-Yu ;

Wu, Tung-Ying ;

Wen, Wu-Che ;

Tsai, Fu-Yu ;

Lee, Ching-Kuo .

JOURNAL OF NATURAL PRODUCTS, 2009, 72 (11) :1960-1963

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