HDL functionality in diabetes mellitus: potential importance of glycation

被引：4
作者：
Younis, Nahla N. [2 ]
Durrington, Paul N. [1 ]
机构：
[1] Univ Manchester, Cardiovasc Res Grp, Sch Biomed, Core Technol Facil, Manchester M13 9NT, Lancs, England
[2] Zagazig Univ, Fac Pharm, Dept Biochem, Zagazig, Egypt
来源：
CLINICAL LIPIDOLOGY | 2012年 / 7卷 / 05期
关键词：
cholesteryl ester transfer protein; diabetes mellitus; dysfunctional HDL; glycation; HDL; lecithin:cholesterol acyl transferase; PON; 1; HIGH-DENSITY-LIPOPROTEIN; CHOLESTERYL ESTER TRANSFER; APOLIPOPROTEIN-A-I; B-CONTAINING LIPOPROTEINS; CORONARY-HEART-DISEASE; SMOOTH-MUSCLE-CELLS; ENDOTHELIUM-DEPENDENT VASORELAXATION; RANDOMIZED CONTROLLED-TRIAL; SERUM PARAOXONASE ACTIVITY; NON ENZYMATIC GLYCATION;
D O I：
10.2217/CLP.12.60
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The incidence of atherosclerotic cardiovascular diseases correlates negatively with HDL. HDL has multiple potentially antiatherogenic properties that may be impaired in diabetes mellitus; in partciular, glycation of HDL could render it functionally deficient. This review explores the possible atheroprotective properties of HDL, the effect of diabetes mellitus and glycation on these properties and therapeutic interventions which could potentially reverse unfavorable deficiencies in HDL functionality.
引用
收藏
页码：561 / 578
页数：18
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